| Autor: |
Czuba LC; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA., Fay EE; Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USA., LaFrance J; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA., Smith CK; Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA 98195, USA., Shum S; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA., Moreni SL; Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USA., Mao J; Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USA., Isoherranen N; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA., Hebert MF; Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA 98195, USA.; Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA 98195, USA. |
| Abstrakt: |
Vitamin A is vital to maternal-fetal health and pregnancy outcomes. However, little is known about pregnancy associated changes in maternal vitamin A homeostasis and concentrations of circulating retinol metabolites. The goal of this study was to characterize retinoid concentrations in healthy women ( n = 23) during two stages of pregnancy (25-28 weeks gestation and 28-32 weeks gestation) as compared to ≥3 months postpartum. It was hypothesized that plasma retinol, retinol binding protein 4 (RBP4), transthyretin and albumin concentrations would decline during pregnancy and return to baseline by 3 months postpartum. At 25-28 weeks gestation, plasma retinol (-27%), 4-oxo-13- cis -retinoic acid (-34%), and albumin (-22%) concentrations were significantly lower, and all-trans -retinoic acid (+48%) concentrations were significantly higher compared to ≥3 months postpartum in healthy women. In addition, at 28-32 weeks gestation, plasma retinol (-41%), retinol binding protein 4 (RBP4; -17%), transthyretin (TTR; -21%), albumin (-26%), 13- cis -retinoic acid (-23%) and 4-oxo-13- cis -retinoic acid (-48%) concentrations were significantly lower, whereas plasma all-trans -retinoic acid concentrations (+30%) were significantly higher than ≥3 months postpartum. Collectively, the data demonstrates that in healthy pregnancies, retinol plasma concentrations are lower, but all-trans -retinoic acid concentrations are higher than postpartum. |
