Adverse effects of dioxins on cognitive ability and motor performance of 5-year-old children residing in a hotspot of dioxin contamination originating from Agent Orange in Vietnam: A prospective cohort study.

Autor: Trang TB; Department of Anatomy, Vietnam Military Medical University, 160-Phung Hung, Ha Dong, Ha Noi, Viet Nam., Tai PT; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung, Ha Dong, Ha Noi, Viet Nam. Electronic address: phamthetai@vmmu.edu.vn., Nishijo M; Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan. Electronic address: ni-koei@kanazawa-med.ac.jp., Anh TN; Department of Anatomy, Vietnam Military Medical University, 160-Phung Hung, Ha Dong, Ha Noi, Viet Nam., Thao PN; Military Hospital 103, Vietnam Military Medical University, 261-Phung Hung, Ha Dong, Ha Noi, Viet Nam., Hoa VT; Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan., Nghi TN; Ministry of Health, 138 A-Giang Vo, Kim Ma, Ba Dinh, Ha Noi, Viet Nam., Van Luong H; Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung, Ha Dong, Ha Noi, Viet Nam., Nishijo H; System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Aug 10; Vol. 833, pp. 155138. Date of Electronic Publication: 2022 Apr 08.
DOI: 10.1016/j.scitotenv.2022.155138
Abstrakt: Bien Hoa airbase is the most dioxin-polluted hotspot in Vietnam. In 2012, a birth cohort living around Bien Hoa airbase was recruited for assessment of physical and neurological development. In the present study, neurodevelopment scores at 5 years of age were assessed by the Kaufman Assessment Battery for Children, Second Edition and the Movement Assessment Battery for Children, Second Edition for 185 children in Bien Hoa and 104 children in Ha Dong (unexposed control group) to clarify the effects of dioxin. 2,3,7,8-tetrachlorodibenzo-p-dioxin concentrations in breast milk of women in Bien Hoa were approximately three times higher than those of women in Ha Dong (2.33 vs. 0.69 pg/g fat, p < 0.001). In general, neurodevelopment scores were lower in Bien Hoa children than in Ha Dong children. In boys, scores differed for number recall (12.6 vs. 14.0, p = 0.036), triangles (10.7 vs. 12.4, p = 0.005), manual dexterity (8.3 vs. 9.7, p = 0.037), balance (7.4 vs. 10.3, p < 0.001), and total movement scores (8.0 vs. 10.1, p = 0.003). After adjusting for covariates, linear regression analysis indicated that the scores of the triangles, balance, and total movement tests were inversely associated with levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and of toxic equivalency of polychlorinated dibenzodioxins and polychlorinated dibenzofurans. In girls, scores differed for the triangles test (11.0 vs. 12.6, p = 0.005), hand movement test (9.6 vs. 11.3, p = 0.003), and balance test (9.1 vs. 10.7, p = 0.050); toxic equivalency of polychlorinated dibenzofurans was inversely associated with hand movement and balance scores. Overall, perinatal dioxin exposure appears to have a long-term impact on neurodevelopment.
Competing Interests: Declaration of competing interest None.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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