Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial Infarction.

Autor: Eriksen E; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Herstad J; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway., Pertiwi KR; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Tuseth V; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Nordrehaug JE; Department of Clinical Science, University of Bergen, Bergen, Norway., Bleie Ø; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway., van der Wal AC; Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Apr 11; Vol. 17 (4), pp. e0266634. Date of Electronic Publication: 2022 Apr 11 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0266634
Abstrakt: Aims: ST elevation myocardial infarction (STEMI) is caused by an occlusive thrombosis of a coronary artery. We wanted to assess if the thrombus can be characterized according to erythrocyte content and age using intravascular optical coherence tomography (OCT) in a clinical setting.
Methods and Results: We performed manual thrombus aspiration in 66 STEMI patients. OCT was done of the thrombus remnants after aspiration. A light intensity ratio was measured through the thrombus. Forty two of the aspirates had thrombus which could be analyzed histomorphologically for analysis of erythrocyte and platelet content, and to determine the age of thrombus as fresh, lytic or organized. There were 11 red, 21 white and 10 mixed thrombi. Furthermore, 36 aspirates had elements of fresh, 7 of lytic and 8 of organized thrombi. There was no correlation between colour and age. OCT appearance could not predict erythrocyte or platelet content. The light intensity ratios were not significantly different in fresh, lytic or organized thrombi.
Conclusion: OCT could not differentiate between red and white thrombi, nor determine thrombus age.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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