Post-traumatic Fungal Keratitis and Endophthalmitis Caused by Coniochaeta Hoffmannii with Late Recurrence following Therapeutic Full-thickness Penetrating Keratoplasty.

Autor: Alsarhani W; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.; Department of Ophthalmology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia., Lam PW; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Kus JV; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Public Health Ontario, Toronto, ON, Canada., Rowsell C; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, St. Michael's Hospital, Unity Health, Toronto, ON, Canada., Tsui GK; Public Health Ontario, Toronto, ON, Canada., Tadros M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada., Fattouh R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, St. Michael's Hospital, Unity Health, Toronto, ON, Canada., Yucel Y; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine, St. Michael's Hospital, Unity Health, Toronto, ON, Canada., Kertes PJ; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.; Department of Ophthalmology & Vision Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Chew HF; Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.; Department of Ophthalmology & Vision Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 May; Vol. 31 (4), pp. 826-829. Date of Electronic Publication: 2022 Apr 11.
DOI: 10.1080/09273948.2022.2048028
Abstrakt: Background: To report a rare case of fungal keratitis and endophthalmitis due to Coniochaeta hoffmannii .
Methods: Case report.
Results: A 71-year-old immunocompetent male sustained a corneal laceration, traumatic cataract, and retinal detachment due to penetrating injury from a nail pulled from a wooden deck. The patient's postoperative course was complicated by infectious keratitis. Fungal cultures, DNA sequencing and analysis of the internal transcribed spacer sequence confirmed Coniochaeta hoffmannii . Topical and oral voriconazole treatments were initiated; however, due to impending perforation, a therapeutic corneal transplant was required. One year later, the patient developed a new corneal infiltrate at the graft-host junction: Corneal scrapings were culture positive for Coniochaeta hoffmannii . This was treated with topical and intrastromal voriconazole along with oral itraconazole 200 mg once daily for 8 months.
Conclusions: Coniochaeta hoffmannii may cause recalcitrant keratitis and endophthalmitis, which required longstanding antifungal treatment.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje