Orbital Mass as the Only Presenting Sign with Overlapping Features of Lupus Erythematosus Panniculitis and Subcutaneous Panniculitis-Like T-Cell Lymphoma.

Autor: Mangan MS; Haydarpasa Numune Education and Research Hospital, Sadik Eratik Eye Institute, Division of Ophthalmic Plastic and Reconstructive Surgery, University of Health Sciences, Istanbul, Turkey., Sarici AM; Cerrahpasa Faculty of Medicine, Department of Ophthalmology, Division of Ocular Oncology, Istanbul University-Cerrahpasa, Istanbul, Turkey., Yalcin O; Okmeydani Education and Research Hospital, Department of Pathology, University of Health Sciences, Istanbul, Turkey., Aydin D; Okmeydani Education and Research Hospital, Department of Internal Medicine, Division of Hematology, University of Health Sciences, Istanbul, Turkey., Yegen G; Istanbul Faculty of Medicine, Department of Pathology, Istanbul University, Istanbul, Turkey., Seyahi E; Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Ocular immunology and inflammation [Ocul Immunol Inflamm] 2023 May; Vol. 31 (4), pp. 717-720. Date of Electronic Publication: 2022 Apr 11.
DOI: 10.1080/09273948.2022.2054430
Abstrakt: Purpose: Even though subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus panniculitis (LEP) are two separate entities, recently they were claimed to represent two ends of a spectrum of T-cell-mediated orbital lymphoproliferative diseases.
Methods: A 78-year-old woman presented with a 1-month history of right-sided periorbital swelling and redness. There was a palpable mass in the medial right lower eyelid with restriction of upward and lateral gaze. MRI revealed a 14 × 7 mm hypointense lesion in the anteromedial orbit.
Results: The systemic and ocular findings, orbital biopsy with histopathology and immunochemistry showed overlapping features of LEP and SPTCL. The patient was consulted with rheumatology and hematology, and the physicians arrived at a consensus that the patient existed in the above-mentioned disease spectrum. She was started on systemic immunosuppressive treatment and her clinical findings improved substantially.
Conclusions: This is the first report of a patient, who presented with orbital mass causing vision loss and gaze restriction that had overlapping clinical and histopathologic features of LEP and SPTCL consistent with this novel disease spectrum, in the literature.
Databáze: MEDLINE
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