The interrelationship of chronic cough and depression: a prospective population-based study.

Autor:	Arinze JT; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., Hofman A; Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., de Roos EW; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., de Ridder MAJ; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., Verhamme KMC; Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Stricker B; Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Brusselle GG; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Dept of Respiratory Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Luik AI; Dept of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2022 Apr 04; Vol. 8 (2). Date of Electronic Publication: 2022 Apr 04 (Print Publication: 2022).
DOI:	10.1183/23120541.00069-2022
Abstrakt:	Background: Chronic cough is a debilitating medical condition that is often complicated by psychomorbidities such as depressive symptoms. Nevertheless, little is known about the impact of chronic cough on the risk of developing depression. Therefore, we investigated the association between chronic cough and prevalent, incident and recurrent depression in a population-based sample of middle-aged and older persons. Methods: Within the Rotterdam Study, a population-based cohort, we defined chronic cough as reporting daily coughing for ⩾3 months. Depression was assessed using the Center for Epidemiologic Studies Depression scale, clinical interviews and medical records. Associations between chronic cough and depression were determined with linear, logistic and Cox regression analyses. Results: The study included 5877 participants (mean±sd age 72±8 years, 59% female) who contributed 37 287 person-years of follow-up. At baseline, participants with chronic cough reported more depressive symptoms (adjusted standardised mean difference 0.15, 95% CI 0.07-0.22) compared to those without chronic cough. Over time, chronic cough was associated with an increased risk of depression in participants with a history of depression (hazard ratio (HR) 1.45, 95% CI 1.13-1.84), but not in those without a history of depression (HR 0.91, 95% CI 0.68-1.22). Conclusions: Adults with chronic cough have a disproportionate burden of depressive symptoms and an increased risk of recurrent depression. This highlights the importance of screening for depression in patients with chronic cough. Competing Interests: Conflict of interest: J.T. Arinze reports support for the present manuscript received from Merck Sharp and Dohme (MSD), support for attending meetings and/or travel received from Lung Foundation Netherlands (Long Fonds), outside the submitted work. G.G. Brusselle reports support for the present manuscript received from MSD, and payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events received from AstraZeneca, GlaxoSmithKline, Boehringer Ingelheim, Novartis, Chiesi, Sanofi and Teva, outside the submitted work. The remaining authors have nothing to disclose. (Copyright ©The authors 2022.)
Databáze:	MEDLINE
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