A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Autor:	Fuloria S; Faculty of Pharmacy, AIMST University, Kedah, Malaysia., Mehta J; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, India., Chandel A; Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, India., Sekar M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Malaysia., Rani NNIM; Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Malaysia., Begum MY; Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Subramaniyan V; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor, Malaysia., Chidambaram K; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia., Thangavelu L; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India., Nordin R; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor, Malaysia., Wu YS; Department of Biological Sciences and Centre for Virus and Vaccine Research, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia., Sathasivam KV; Faculty of Applied Sciences, AIMST University, Kedah, Malaysia., Lum PT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Malaysia., Meenakshi DU; College of Pharmacy, National University of Science and Technology, Muscat, Oman., Kumarasamy V; Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor, Malaysia.; Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Perak, Malaysia., Azad AK; Faculty of Pharmacy, AIMST University, Kedah, Malaysia., Fuloria NK; Faculty of Pharmacy, AIMST University, Kedah, Malaysia.; Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 Mar 25; Vol. 13, pp. 820806. Date of Electronic Publication: 2022 Mar 25 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.820806
Abstrakt:	Curcuma longa Linn. ( C. longa ), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of C. longa , is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of C. longa in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about C. longa in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of C. longa on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of C. longa and curcumin. This prompts further preclinical and clinical investigations on curcumin. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with one of the authors MS. (Copyright © 2022 Fuloria, Mehta, Chandel, Sekar, Rani, Begum, Subramaniyan, Chidambaram, Thangavelu, Nordin, Wu, Sathasivam, Lum, Meenakshi, Kumarasamy, Azad and Fuloria.)
Databáze:	MEDLINE
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