Exploring the Recent Trends in Management of Dementia and Frailty: Focus on Diagnosis and Treatment.

Autor:	Rahman MM; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Mim SA; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Islam MR; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Parvez A; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Islam F; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Uddin MB; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Rahaman MS; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Shuvo PA; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Ahmed M; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh., Greig NH; Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Kamal MA; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka- 1207, Bangladesh.; Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.; King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia.; NSW; Novel Global Community Educational Foundation, Peterlee Place, Hebersham, NSW 2770, Australia.
Jazyk:	angličtina
Zdroj:	Current medicinal chemistry [Curr Med Chem] 2022; Vol. 29 (32), pp. 5289-5314.
DOI:	10.2174/0929867329666220408102051
Abstrakt:	Dementia and frailty increase health adversities in older adults, which are topics of growing research interest. Frailty is considered to correspond to a biological syndrome associated with age. Frail patients may ultimately develop multiple dysfunctions across several systems, including stroke, transient ischemic attack, vascular dementia, Parkinson's disease, Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, cortico-basal degeneration, multiple system atrophy, amyotrophic lateral sclerosis, and Creutzfeldt-Jakob disease. Patients with dementia and frailty often develop malnutrition and weight loss. Rigorous nutritional, pharmacological, and non-pharmacological interventions generally are required for these patients, which is a challenging issue for healthcare providers. A healthy diet and lifestyle instigated at an early age can reduce the risk of frailty and dementia. For optimal treatment, accurate diagnosis involving clinical evaluation, cognitive screening, essential laboratory evaluation, structural imaging, functional neuroimaging, and neuropsychological testing is necessary. Diagnosis procedures best apply the clinical diagnosis, identifying the cause(s) and the condition(s) appropriate for treatment. The patient's history, caregiver's interview, physical examination, cognitive evaluation, laboratory tests, and structural imaging should best be involved in the diagnostic process. Varying types of physical exercise can aid the treatment of these disorders. Nutrition maintenance is a particularly significant factor, such as exceptionally high-calorie dietary supplements and a Mediterranean diet to support weight gain. The core purpose of this article is to investigate trends in the management of dementia and frailty, focusing on improving diagnosis and treatment. Substantial evidence builds the consensus that a combination of balanced nutrition and good physical activity is an integral part of treatment. Notably, more evidence-based medicine knowledge is required. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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