Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic.

Autor:	Liang C; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Hui N; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Liu Y; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Qiao G; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Li J; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Tian L; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Ju X; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Jia M; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Liu H; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai 519030, PR China., Cao W; Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Hengqin New Area, Zhuhai 519030, PR China., Yu P; School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China., Li H; Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, PR China., Ren X; Medical College, Guizhou University, Guiyang 550025, PR China.
Jazyk:	angličtina
Zdroj:	Phytomedicine plus : international journal of phytotherapy and phytopharmacology [Phytomed Plus] 2021 May; Vol. 1 (2), pp. 100027. Date of Electronic Publication: 2021 Jan 16.
DOI:	10.1016/j.phyplu.2021.100027
Abstrakt:	Background: In December 2019, a novel coronavirus, SARS-CoV-2 caused a series of acute atypical respiratory diseases worldwide. However, there is still a lack of drugs with clear curative effects, and the clinical trial research of vaccines has not been completely finished. Purpose: LH capsules are approved TCM patent medicine that are widely used for the treatment of respiratory tract infectious diseases caused by colds and flu. On April 12, 2020, LH capsules and granules were officially repurposed by the China Food and Drug Administration (CFDA) for patients with mild COVID-19 based on their safety and efficacy demonstrated through multicentre, randomized, controlled clinical trials. We hope to conduct a comprehensive review of it through modern pharmacy methods, and try to explain its possible mechanism. Methods: Using the full names of LH capsules Lianhuaqingwen, Lianhua Qingwen andSARS-COV-2, COVID-19 as the keywords of the search terms, systemically search for existing related papers in various databases such as Web of Science and PubMed. And completed the collection of clinical data in ClinicalTrials.gov and Chinese Clinical Trial Registry. Last but not least, we have sorted out the anti-inflammatory and antiviral mechanisms of LH capsules through literature and Selleck. Results: This review systematically sorted out the active ingredients in LH capsules. Furthermore, the related pharmacological and clinical trials of LH capsule on SARS-CoV-2, IAV and IBV were discussed in detail. Moreover, the present review provides the first summary of the potential molecular mechanism of specific substances in LH capsules involved in resistance to SARS-COV-2 infection and the inhibition of cytokine storm syndrome (CSS) caused by IL-6. Conclusion: This review summarizes the available reports and evidence that support the use of LH capsules as potential drug candidates for the prevention and treatment of COVID-19. However, TCM exerts its effects through multiple targets and multiple pathways, and LH capsules are not an exception. Therefore, the relevant mechanisms need to be further improved and experimentally verified. Competing Interests: We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. (© 2021 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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