Impact of Hypertensive Disorders of Pregnancy on Stillbirth and Other Perinatal Outcomes: A Multi-Center Retrospective Study.

Autor:	Basta M; School of Medicine, St. George's University, True Blue, GRD., Hanif K; Medicine, Ayub Medical College, Abbottabad, PAK., Zafar S; Biological Sciences, Victoria University of Wellington, School of Biological Sciences, Wellington, NZL., Khabazeh A; Faculty of Medicine, Damascus University, Damascus, SYR., Amin F; Medicine, Quaid e Azam Medical College, Bahawalpur, PAK., Sharif Khan S; Medicine, Aga Khan University Hospital, Karachi, PAK., Ghaffar U; Internal Medicine, Nishtar Medical University and Hospital, Multan, PAK., Mohammed Saeed Muthanna F; Department of Pharmaceutical Care, Walailak University, Nakhon Si Thammarat, THA., Wali S; Research, Aga Khan University, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Mar 03; Vol. 14 (3), pp. e22788. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022).
DOI:	10.7759/cureus.22788
Abstrakt:	Objective: The aim of the study is to assess the impact of hypertensive disorders of pregnancy on stillbirths and other perinatal outcomes among women in Karachi, Pakistan. Methodology: This was a retrospective cohort study conducted at two tertiary care hospitals, Aga Khan Hospital (AKU) and Liaquat National Hospital (LNH) in Karachi, Pakistan. The primary outcome variable of this study was stillbirth. Other outcomes assessed in this study included preterm birth, low birth weight, and early neonatal death. Results: Data of a total of 840 women were included in this study; 280 (33.33%) women had hypertensive disorders of pregnancy and 560 (66.67%) were normotensive. Among women who had hypertensive disorders of pregnancy, the adjusted odds ratio (AOR) of having a stillbirth was two times more than that for normotensive women (AOR=2.62, 95% CI=1.46-4.40), four times for low birth weight (AOR=4.23, 95% CI=2.88-6.20), five times for early neonatal death (AOR=5.03, 95% CI=2.40-10.50) and six times for pre-term birth (AOR=5.16, 95% CI=3.42-7.79). Conclusion: The current study found that incidence of stillbirth, low birth weight, pre-term birth, and neonatal mortality is higher in mothers with hypertensive disorders of pregnancy than normotensive mothers. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Basta et al.)
Databáze:	MEDLINE
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