A Case Report of Radiotherapy for Skull Lesions of Langerhans Cell Histiocytosis With Dural Invasion.

Autor:	Hiroshima Y; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan.; QST Hospital, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan., Tamaki Y; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Sawada T; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Murakami M; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Ishida T; Department of Radiation Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan.; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Saitoh T; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Kojima H; Ibaraki Clinical Education and Training Center, University of Tsukuba Hospital, Kasama, Japan.; Department of Medical Oncology, Ibaraki Prefectural Central Hospital, Kasama, Japan., Okumura T; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan., Sakurai H; Department of Radiation Oncology, Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba, Japan.
Jazyk:	angličtina
Zdroj:	Cancer diagnosis & prognosis [Cancer Diagn Progn] 2022 Mar 03; Vol. 2 (2), pp. 258-262. Date of Electronic Publication: 2022 Mar 03 (Print Publication: 2022).
DOI:	10.21873/cdp.10103
Abstrakt:	Background: Langerhans cell histiocytosis (LCH) is a rare disease, especially in adults. It is often associated with non-fatal bone and skin lesions and has relatively good radiosensitivity. In contrast, brain and lymph node metastases from LCH lesions are considered to be less sensitive to radiotherapy. Case Report: At our institution, 30 Gy radiotherapy was used to treat bone lesions with dural invasion in a patient with adult-onset LCH. The patient was treated with chemotherapy and radiotherapy for 21 years since the initial diagnosis. After radiotherapy, the tumor shrank rapidly, and a complete response was achieved 1 year after treatment. The patient survived without local recurrence. Conclusion: Here, we report the details of this case, along with a review of the literature. We suggest that even with invasion of the tissues around the bone lesions in LCH, local recurrence can be prevented by middle radiation doses. Competing Interests: The Authors declare no conflicts of interest in relation to this report. (Copyright 2022, International Institute of Anticancer Research.)
Databáze:	MEDLINE
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