Risperidone on apomorphine-induced stereotyped behavior and auditory sensory gating in rhesus monkeys.

Autor: Iwamura Y; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Nakako T; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Matsumoto A; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Ogi Y; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Yamaguchi M; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Kobayashi A; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Matsumoto K; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Katsura Y; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan., Ikeda K; Platform Technology Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd., Osaka, Japan. Electronic address: kazuhito-ikeda@ds-pharma.co.jp.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2022 Jun 25; Vol. 428, pp. 113883. Date of Electronic Publication: 2022 Apr 06.
DOI: 10.1016/j.bbr.2022.113883
Abstrakt: The ameliorating effect of risperidone on apomorphine-induced stereotyped behavior and inhibition of auditory sensory gating was investigated using rhesus monkeys. The total duration of the stereotyped behavior observed in the control group was 43.7 ± 23.0 s (n = 3) between 10 and 25 min after vehicle administration, whereas the duration in the apomorphine-treated (0.1 or 0.15 mg/kg i.m., n = 3) group was observed to be significantly prolonged to 413.0 ± 150.6 s. Administration of 0.01, 0.03, 0.1 mg/kg of risperidone 60 min before apomorphine, significantly reduced the duration of this apomorphine-induced stereotyped behavior to 327 ± 104.9 s (n = 3), 8.3 ± 4.2 s (n = 3), and 0.0 ± × 0.0 s (n = 3, t-test: p < 0.05), respectively. Next, the auditory sensory gating test/conditioning (T/C) ratio was used as a bio-marker. The T/C ratio was 0.598 ± 0.0802 in the vehicle-administered control group (n = 4) and was significantly increased to 2.098 ± 0.254 (n = 4) by apomorphine (0.15 mg/kg, i.m.). Administering of risperidone (0.1 mg/kg, s.c.) 30 min before apomorphine treatment significantly restricted the T/C ratio to 0.571 ± 0.0886 (n = 4), compared to the T/C ratio in the vehicle-administered control group. The above results demonstrate, not only behaviorally but also electrophysiologically, the ameliorating effect of risperidone on the induction of schizophrenia-like symptoms by apomorphine in non-human primates.
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Databáze: MEDLINE