Predictive models for first-onset and persistence of depression and anxiety among university students.

Autor: Ballester L; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; Girona University (UdG), Girona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Alayo I; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Vilagut G; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Mortier P; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Almenara J; University of Cádiz (UCA), Spain., Cebrià AI; Department of Mental Health, Corporació Sanitaria Parc Taulí, Sabadell, Spain; CIBER Salud Mental (CIBERSAM), Madrid, Spain., Echeburúa E; University of the Basque Country (UPV-EHU), San Sebastián, Spain., Gabilondo A; BioDonostia Health Research Institute, Osakidetza, San Sebastián, Spain., Gili M; Institut Universitari d'Investigació en Ciències de la Salut (IUNICS-IDISBA), Rediapp, University of Balearic Islands (UIB), Palma de Mallorca, Spain., Lagares C; University of Cádiz (UCA), Spain., Piqueras JA; Miguel Hernandez University of Elche (UMH), Spain., Roca M; Institut Universitari d'Investigació en Ciències de la Salut (IUNICS-IDISBA), Rediapp, University of Balearic Islands (UIB), Palma de Mallorca, Spain., Soto-Sanz V; Miguel Hernandez University of Elche (UMH), Spain., Blasco MJ; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Castellví P; International University of Catalonia (UIC), Barcelona, Spain., Miranda-Mendizabal A; International University of Catalonia (UIC), Barcelona, Spain., Bruffaerts R; Universitair Psychiatrisch Centrum (UPC-KUL), Center for Public Health Psychiatry, KULeuven, Leuven, Belgium., Auerbach RP; Department of Psychiatry, Columbia University, New York, United States., Nock MK; Department of Psychology, Harvard University, Boston, MA, United States., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, United States., Alonso J; Health Services Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Medicine and Life Scienes, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: jalonso@imim.es.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2022 Jul 01; Vol. 308, pp. 432-441. Date of Electronic Publication: 2022 Apr 06.
DOI: 10.1016/j.jad.2021.10.135
Abstrakt: Background: Depression and anxiety are both prevalent among university students. They frequently co-occur and share risk factors. Yet few studies have focused on identifying students at highest risk of first-onset and persistence of either of these conditions.
Methods: Multicenter cohort study among Spanish first-year university students. At baseline, students were assessed for lifetime and 12-month Major Depressive Episode and/or Generalized Anxiety Disorder (MDE-GAD), other mental disorders, childhood-adolescent adversities, stressful life events, social support, socio-demographics, and psychological factors using web-based surveys; 12-month MDE-GAD was again assessed at 12-month follow-up.
Results: A total of 1253 students participated in both surveys (59.2% of baseline respondents; mean age = 18.7 (SD = 1.3); 56.0% female). First-onset of MDE-GAD at follow-up was 13.3%. Also 46.7% of those with baseline MDE-GAD showed persistence at follow-up. Childhood/Adolescence emotional abuse or neglect (OR= 4.33), prior bipolar spectrum disorder (OR= 4.34), prior suicidal ideation (OR=4.85) and prior lifetime symptoms of MDE (ORs=2.33-3.63) and GAD (ORs=2.15-3.75) were strongest predictors of first-onset MDE-GAD. Prior suicidal ideation (OR=3.17) and prior lifetime GAD symptoms (ORs=2.38-4.02) were strongest predictors of MDE-GAD persistence. Multivariable predictions from baseline showed AUCs of 0.76 for first-onset and 0.81 for persistence. 74.9% of first-onset MDE-GAD cases occurred among 30% students with highest predicted risk at baseline.
Limitations: Self-report data were used; external validation of the multivariable prediction models is needed.
Conclusion: MDE-GAD among university students is frequent, suggesting the need to implement web-based screening at university entrance that identify those students with highest risk.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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