Prognosis and chemosensitivity of non-colorectal alimentary tract cancers with microsatellite instability.

Autor: Boyer C; Hepato-Gastroenterology Department, Poitiers University Hospital, University of Poitiers, 2 rue de la Milétrie, Poitiers 86000, France., Sefrioui D; Department of Hepatogastroenterology, Normandie Univ, UNIROUEN, Inserm U1245, IRON group, Rouen University Hospital, Rouen 76000, France., Cohen R; Medical Oncology Department, Assistance Publique-Hôpitaux de Pari, Saint Antoine Hospital, Sorbonne University, Paris 75012, France., Chautard R; Department of Hepato-Gastroenterology and Digestive Oncology, Tours University hospital, Tours 37000, France., Perrier M; Department of Hepato-Gastroenterology and Digestive Oncology, Robert-Debré University Hospital, Reims 51000, France., Lebrun H; Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille University, Lille 59000, France., Goujon G; Gastroenterology Department, Bichat Hospital, Paris 75018, France., Hautefeuille V; Department of Hepato-Gastroenterology and Digestive Oncology, Hôpital Sud, Amiens 80000, France., Dior M; Department of Hepato-Gastroenterology and Digestive Oncology, Louis Mourier Hospital, Colombes 92700, France., Walter T; Department of Digestive Oncology, Edouard Herriot Hospital, Lyon 69000, France., Mary F; Gastroenterology Department, Avicenne Hospital, Bobigny 93000, France., Manfredi S; Department of Hepato-Gastroenterology and Digestive Oncology, Dijon University hospital, Dijon 21000, France., Caroli-Bosc FX; Department of Hepato-Gastroenterology and Digestive Oncology, Angers University hospital, Angers 49000, France., Cervantes B; Department of Medical Oncology, Institut Mutualiste Montsouris, Paris 75014, France., Coriat R; Department of Hepato-Gastroenterology and Digestive Oncology, Cochin Hospital, Paris 75014, France., Deluche E; Department of Medical Oncology, Limoges University Hospital, Limoges 87000, France., Zaanan A; Department of Gastroenterology and Digestive Oncology, Assistance Publique-Hôpitaux de Paris, European Georges Pompidou Hospital, Paris, 75015, France., Olivier R; Hepato-Gastroenterology Department, Poitiers University Hospital, University of Poitiers, 2 rue de la Milétrie, Poitiers 86000, France., Bouché O; Department of Hepato-Gastroenterology and Digestive Oncology, Robert-Debré University Hospital, Reims 51000, France., Piessen G; Department of Digestive and Oncological Surgery, Claude Huriez University Hospital, Lille University, Lille 59000, France., Lecomte T; Department of Hepato-Gastroenterology and Digestive Oncology, Tours University hospital, Tours 37000, France., Louvet C; Department of Medical Oncology, Institut Mutualiste Montsouris, Paris 75014, France., Michel P; Department of Hepatogastroenterology, Normandie Univ, UNIROUEN, Inserm U1245, IRON group, Rouen University Hospital, Rouen 76000, France., Aparicio T; Gastroenterology and Digestive Oncology Department, Assistance Publique-Hôpitaux de Paris, Saint Louis Hospital, Paris University, Paris 75010, France., André T; Medical Oncology Department, Assistance Publique-Hôpitaux de Pari, Saint Antoine Hospital, Sorbonne University, Paris 75012, France., Taieb J; Department of Gastroenterology and Digestive Oncology, Assistance Publique-Hôpitaux de Paris, European Georges Pompidou Hospital, Paris, 75015, France., Randrian V; Hepato-Gastroenterology Department, Poitiers University Hospital, University of Poitiers, 2 rue de la Milétrie, Poitiers 86000, France., Tougeron D; Hepato-Gastroenterology Department, Poitiers University Hospital, University of Poitiers, 2 rue de la Milétrie, Poitiers 86000, France. Electronic address: david.tougeron@chu-poitiers.fr.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2023 Jan; Vol. 55 (1), pp. 123-130. Date of Electronic Publication: 2022 Apr 06.
DOI: 10.1016/j.dld.2022.03.011
Abstrakt: Background: Data on outcomes of microsatellite instable and/or mismatch repair deficient (dMMR/MSI) digestive non-colorectal tumors are limited.
Aims: To evaluate overall survival (OS) of patients with dMMR/MSI digestive non-colorectal tumor.
Methods: All consecutive patients with a dMMR/MSI digestive non-colorectal tumor were included in this French retrospective multicenter study.
Results: One hundred and sixteen patients were included with a mean age of 63.6 years and 32.6% with a Lynch syndrome. Most tumors were oesophago-gastric (54.3%) or small bowel (32.8%) adenocarcinomas and at a localized stage at diagnosis (86.7%). In patients with localized tumors and R0 resection, median OS was 134.0 ± 64.2 months. Median disease-free survival (DFS) was 100.3 ± 65.7 months. Considering oesophago-gastric tumors, median DFS was improved when chemotherapy was added to surgery (not reached versus 22.8 ± 10.0 months, p = 0.03). In patients with advanced tumors treated by chemotherapy, median OS was 14.2 ± 1.9 months and median progression-free survival was 7.4 ± 1.6 months.
Conclusion: dMMR/MSI digestive non-colorectal tumors are mostly diagnosed at a non-metastatic stage with a good prognosis. Advanced dMMR/MSI digestive non-colorectal tumors have a poor prognosis with standard chemotherapy.
Competing Interests: Conflict of interest None declared.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: