Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø.

Autor: Dong C; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France.; Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris and Université Paris-Saclay, Le Kremlin Bicêtre, France., Chan SSM; Norwich Medical School, Department of Medicine, University of East Anglia, Norwich, UK.; Department of Gastroenterology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK., Jantchou P; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France.; Sainte Justine University Hospital, Montréal, QC, Canada., Racine A; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France.; Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris and Université Paris-Saclay, Le Kremlin Bicêtre, France., Oldenburg B; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands., Weiderpass E; International Agency for Research on Cancer, World Health Organization, Lyon, France., Heath AK; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Tong TYN; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Tjønneland A; Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Kyrø C; Danish Cancer Society Research Center, Copenhagen, Denmark., Bueno de Mesquita B; National Institute for Public Health and the Environment [RIVM], Bilthoven, The Netherlands., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Katzke VA; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Bergman MM; Department of Epidemiology, German Institute of Human Nutrition, Potsdam, Germany., Boeing H; Department of Epidemiology, German Institute of Human Nutrition, Potsdam, Germany., Palli D; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy., Masala G; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy., Tumino R; Cancer Registry and Histopathology Department, Azienda Sanitaria Provinciale, Ragusa, Italy., Sacerdote C; Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy., Colorado-Yohar SM; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.; CIBER Epidemiologia y Salud Pública [CIBERESP], Madrid, Spain.; National School of Public Health, Research Group on Demography and Health, University of Antioquia, Medellín, Colombia., Sánchez MJ; CIBER Epidemiologia y Salud Pública [CIBERESP], Madrid, Spain.; Escuela Andaluza de Salud Pública [EASP], Granada, Spain.; Instituto de Investigación Biosanitaria, Granada, Spain.; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain., Grip O; Department of Gastroenterology and Hepatology, University Hospital Malmö, Malmö, Sweden., Lindgren S; Department of Gastroenterology and Hepatology, University Hospital Malmö, Malmö, Sweden., Luben R; Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Cambridge, UK., Huybrechts I; International Agency for Research on Cancer, World Health Organization, Lyon, France., Gunter MJ; International Agency for Research on Cancer, World Health Organization, Lyon, France., Mahamat-Saleh Y; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France., Boutron-Ruault MC; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France., Carbonnel F; INSERM, Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy, Université Paris Saclay, Villejuif, France.; Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris and Université Paris-Saclay, Le Kremlin Bicêtre, France.
Jazyk: angličtina
Zdroj: Journal of Crohn's & colitis [J Crohns Colitis] 2022 Aug 30; Vol. 16 (8), pp. 1187-1196.
DOI: 10.1093/ecco-jcc/jjac054
Abstrakt: Background and Aims: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease [IBD] in the European Prospective Investigation into Cancer and Nutrition.
Methods: A total of 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors in measures related to each country-specific questionnaire. Associations between proteins [total, animal, and vegetable] or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.
Results: After a mean follow-up of 16 years, 177 patients with Crohn's disease [CD] and 418 with ulcerative colitis [UC], were identified. There was no association between total protein, animal protein, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (hazard ratio [HR] for the 4th vs 1st quartile = 1.40, 95% confidence interval [CI] = 0.99-1.98, p-trend = 0.01; and 1.61, 95% CI = 1.10-2.36, p-trend = 0.007, respectively]. There was no association between other food sources of animal protein [processed meat, fish, shellfish, eggs, poultry] and UC. We found no association between food sources of animal proteins and CD risk.
Conclusions: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counselling of low meat intake in people at high-risk of IBD.
(© The Author(s) 2022. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze: MEDLINE
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