Corpus callosum injury after neurosurgical intervention for posthemorrhagic ventricular dilatation and association with neurodevelopmental outcome at 2 years.

Autor:	Cizmeci MN; 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University.; 2University Medical Center Utrecht, Utrecht Brain Center, Utrecht, The Netherlands.; 3Division of Neonatology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto., Groenendaal F; 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University.; 2University Medical Center Utrecht, Utrecht Brain Center, Utrecht, The Netherlands., van der Aa NE; 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University.; 2University Medical Center Utrecht, Utrecht Brain Center, Utrecht, The Netherlands., Vandewouw MM; 4Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto.; 5Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto.; 6Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto.; 7Institute of Biomedical Engineering, University of Toronto., Young JM; 5Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto.; 8Department of Psychology, The Hospital for Sick Children, University of Toronto, Ontario, Canada., Han K; 9Department of Neurosurgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University, Utrecht; and., Benders MJNL; 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University.; 2University Medical Center Utrecht, Utrecht Brain Center, Utrecht, The Netherlands., Taylor MJ; 4Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto.; 5Program in Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto., de Vries LS; 1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University.; 2University Medical Center Utrecht, Utrecht Brain Center, Utrecht, The Netherlands.; 10Department of Neonatology, Leiden University Medical Center, Leiden, The Netherlands., Woerdeman PA; 9Department of Neurosurgery, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University, Utrecht; and.
Jazyk:	angličtina
Zdroj:	Journal of neurosurgery. Pediatrics [J Neurosurg Pediatr] 2022 Apr 08; Vol. 30 (1), pp. 31-38. Date of Electronic Publication: 2022 Apr 08 (Print Publication: 2022).
DOI:	10.3171/2022.2.PEDS21577
Abstrakt:	Objective: Direct injury to the corpus callosum (CC) due to neurosurgical interventions in infants with posthemorrhagic ventricular dilatation (PHVD) has not been reported in the literature. The authors observed a subset of infants who had suffered penetrating CC injury after neurosurgical interventions for PHVD and hypothesized that this pattern of injury may result in suboptimal CC maturation and neurodevelopmental impairment. Methods: In this multicenter, retrospective, observational study, 100 preterm and 17 full-term infants with PHVD were included and compared with 23 preterm controls. Both neonatal and postneonatal brain MRI scans were assessed for injury, and measurements were performed on postneonatal MRI scans at 2 years' corrected age. Neurodevelopmental outcome was assessed at 2 years' corrected age. Results: A total of 269 brain MRI scans of 140 infants were included. Of infants with PHVD, 48 (41%) had penetrating CC injury following neurosurgical interventions. The median (IQR) CC midsagittal surface area was smaller in infants with CC injury when compared with infants with PHVD who had intact CC and controls (190 mm2 [149-262 mm2] vs 268 mm2 [206-318 mm2] vs 289 mm2 [246-320 mm2], respectively; p < 0.001). In the univariate analysis, the area of the CC was associated with cognitive Z score (coefficient 0.009 [95% CI 0.005-0.012], p < 0.001) and motor Z score (coefficient 0.009 [95% CI 0.006-0.012], p < 0.001). In the multivariable model, CC injury was not independently associated with cognitive and motor Z score after adjusting for gestational age and presence of periventricular hemorrhagic infarction (coefficient 0.04 [95% CI -0.36 to 0.46] and -0.37 [95% CI -0.83 to 0.09], p = 0.7 and 0.1, respectively). Conclusions: CC injury was not uncommon following neurosurgical interventions for PHVD in both preterm and full-term infants. At the age of 2 years, the CC midsagittal surface area was smaller in infants with injury, but CC injury was not independently associated with cognitive and motor outcomes at 2 years' corrected age.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu