Emerging Insights into the Impact of Air Pollution on Immune-Mediated Asthma Pathogenesis.
Autor: | Tuazon JA; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Medical Scientist Training Program, The Ohio State University, Columbus, OH, 43210, USA., Kilburg-Basnyat B; Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC, 27858, USA., Oldfield LM; Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, Rockville, MD, 20850, USA.; Department of Synthetic Genomics, Replay Holdings LLC, San Diego, 92121, USA., Wiscovitch-Russo R; Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, Rockville, MD, 20850, USA., Dunigan-Russell K; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Davis Heart and Lung Research Institute, Columbus, OH, 43210, USA., Fedulov AV; Division of Surgical Research, Department of Surgery, Alpert Medical School, Brown University, Rhode Island Hospital, Providence, RI, 02903, USA., Oestreich KJ; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.; Pelotonia Institute for Immuno-Oncology, The Ohio State University, The James Comprehensive Cancer Center, Columbus, OH, 43210, USA., Gowdy KM; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Davis Heart and Lung Research Institute, Columbus, OH, 43210, USA. kymberly.gowdy@osumc.edu. |
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Jazyk: | angličtina |
Zdroj: | Current allergy and asthma reports [Curr Allergy Asthma Rep] 2022 Jul; Vol. 22 (7), pp. 77-92. Date of Electronic Publication: 2022 Apr 08. |
DOI: | 10.1007/s11882-022-01034-1 |
Abstrakt: | Purpose of Review: Increases in ambient levels of air pollutants have been linked to lung inflammation and remodeling, processes that lead to the development and exacerbation of allergic asthma. Conventional research has focused on the role of CD4 + T helper 2 (T Recent Findings: In this article, we review current research demonstrating the connection between common air pollutants and their downstream effects on non-T (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
Databáze: | MEDLINE |
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