| Autor: |
Kamau RW; Department of Chemistry, School of Natural and Applied Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya.; Department of Chemistry, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania., Masila VM; Department of Chemistry, School of Physical Sciences, University of Nairobi, Nairobi, Kenya., Midiwo JO; Department of Chemistry, School of Physical Sciences, University of Nairobi, Nairobi, Kenya., Mgani QA; Department of Chemistry, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania., Kumarihamy M; National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA., Wang M; Natural Products Utilization Research Unit, Agricultural Research Service, U.S. Department of Agriculture, University, MS, USA., Zhao J; National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA., Muhammad I; National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA. |
| Abstrakt: |
A new 3,8''-flavanone-flavonol dimer gnidiflavanone-flavonol ( 1 ) and 10 known compounds ( 2 - 11 ), including four rare primula-type flavones 2 - 5 , were isolated from the roots of Gnidia apiculata . Compounds 2 - 5 and 7 were reported for the first time from the plant family Thymelaeceae. Structures of the isolated compounds were established by spectroscopic data, including 1D and 2D NMR (COSY, HMBC, HSQC and ROESY) and mass spectrometry, as well as by the comparison with literature data. The crude roots extract and isolated compounds were evaluated for antimicrobial and antiplasmodial activities. Among isolated compounds, 6-hydroxyflavone ( 4 ) and 6- O -acetylflavone ( 4a ) showed antiplasmodial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum . |
