Liver steatosis, cardiac and renal fibrosis, and hypertension in overweight rats: Angiotensin-(3-4)-sensitive hepatocardiorenal syndrome.

Autor:	Crisóstomo T; Leopoldo de Meis Institute of Medical Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; National Center of Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pardal MAE; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Herdy SA; Graduate Program in Translational Biomedicine/BIOTRANS, University of Grande Rio, Duque de Caxias, Brazil., Muzi-Filho H; National Center of Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Mello DB; National Center of Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Takiya CM; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Luzes R; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Graduate Program in Translational Biomedicine/BIOTRANS, University of Grande Rio, Duque de Caxias, Brazil., Vieyra A; National Center of Structural Biology and Bioimaging/CENABIO, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Graduate Program in Translational Biomedicine/BIOTRANS, University of Grande Rio, Duque de Caxias, Brazil.
Jazyk:	angličtina
Zdroj:	Metabolism open [Metabol Open] 2022 Mar 18; Vol. 14, pp. 100176. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022).
DOI:	10.1016/j.metop.2022.100176
Abstrakt:	Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke hepatocardiorenal syndrome resulting from activation of the Ang II→type 1 receptor axis, which is entirely counteracted by Ang-(3-4), the allosteric enhancer of the Ang II→type 2 receptor pathway. Competing Interests: The authors declare no conflict of interest. (© 2022 The Authors.)
Databáze:	MEDLINE
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