Deletions of the Plasmodium falciparum histidine-rich protein 2/3 genes are common in field isolates from north-eastern Tanzania.

Autor: Kaaya RD; Kilimanjaro Christian Medical University College, Moshi, Tanzania. robertkaaya@yahoo.com.; Pan-African Malaria Vector Research Consortium, Moshi, Tanzania. robertkaaya@yahoo.com., Kavishe RA; Kilimanjaro Christian Medical University College, Moshi, Tanzania., Tenu FF; Pan-African Malaria Vector Research Consortium, Moshi, Tanzania., Matowo JJ; Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Pan-African Malaria Vector Research Consortium, Moshi, Tanzania., Mosha FW; Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Pan-African Malaria Vector Research Consortium, Moshi, Tanzania., Drakeley C; Department of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Sutherland CJ; Department of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Beshir KB; Department of Infection Biology, Faculty of Infectious & Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Apr 06; Vol. 12 (1), pp. 5802. Date of Electronic Publication: 2022 Apr 06.
DOI: 10.1038/s41598-022-09878-3
Abstrakt: Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3 (pfhrp2/3) genes have been reported in several parts of the world. These deletions are known to compromise the effectiveness of HRP2-based malaria rapid diagnostic tests (HRP2-RDT). The National Malaria Control Programme (NMCP) in Tanzania adopted HRP2-RDTs as a routine tool for malaria diagnosis in 2009 replacing microscopy in many Health facilities. We investigated pfhrp2/3 deletions in 122 samples from two areas with diverse malaria transmission intensities in Northeastern Tanzania. Pfhrp2 deletion was confirmed in 1.6% of samples while pfhrp3 deletion was confirmed in 50% of samples. We did not find parasites with both pfhrp2 and pfhrp3 deletions among our samples. Results from this study highlight the need for systematic surveillance of pfhrp2/3 deletions in Tanzania to understand their prevalence and determine their impact on the performance of mRDT.
(© 2022. The Author(s).)
Databáze: MEDLINE
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