Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways.
| Autor: | Emwas AH; King Abdullah University of Science and Technology, Core Labs, Thuwal, Saudi Arabia., Szczepski K; Smart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Al-Younis I; King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences & Engineering Division (BESE), Thuwal, Saudi Arabia., Lachowicz JI; Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, Monserrato, Italy., Jaremko M; Smart-Health Initiative (SHI) and Red Sea Research Center (RSRC), Biological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in pharmacology [Front Pharmacol] 2022 Mar 21; Vol. 13, pp. 805782. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022). |
| DOI: | 10.3389/fphar.2022.805782 |
| Abstrakt: | Fluxomics is an innovative -omics research field that measures the rates of all intracellular fluxes in the central metabolism of biological systems. Fluxomics gathers data from multiple different -omics fields, portraying the whole picture of molecular interactions. Recently, fluxomics has become one of the most relevant approaches to investigate metabolic phenotypes. Metabolic flux using 13 C-labeled molecules is increasingly used to monitor metabolic pathways, to probe the corresponding gene-RNA and protein-metabolite interaction networks in actual time. Thus, fluxomics reveals the functioning of multi-molecular metabolic pathways and is increasingly applied in biotechnology and pharmacology. Here, we describe the main fluxomics approaches and experimental platforms. Moreover, we summarize recent fluxomic results in different biological systems. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Emwas, Szczepski, Al-Younis, Lachowicz and Jaremko.) |
| Databáze: | MEDLINE |
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