In vitro degradation, photo-dynamic and thermal antibacterial activities of Cu-bearing chlorophyllin-induced Ca-P coating on magnesium alloy AZ31.
| Autor: | Zhang ZY; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., An YL; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Wang XS; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Cui LY; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Li SQ; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Liu CB; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Zou YH; College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Zhang F; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China., Zeng RC; College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.; School of Materials Science and Engineering, Zhengzhou University, Zhengzhou, 450002, China. |
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| Jazyk: | angličtina |
| Zdroj: | Bioactive materials [Bioact Mater] 2022 Feb 15; Vol. 18, pp. 284-299. Date of Electronic Publication: 2022 Feb 15 (Print Publication: 2022). |
| DOI: | 10.1016/j.bioactmat.2022.01.050 |
| Abstrakt: | Surgical failures, caused by postoperative infections of bone implants, are commonly met, which cannot be treated precisely with intravenous antibiotics. Photothermal therapy (PTT) and photodynamic therapy (PDT) have attracted widespread attention due to their non-invasive antibacterial effects on tissues and no bacterial resistance, which may be an excellent approach to solve infections related to bone implants for biodegradable magnesium alloys. Herein, a sodium copper chlorophyllin (SCC) with a porphyrin ring induced Ca-P coating was prepared on AZ31 magnesium alloy via layer-by-layer (LbL) assembly. The morphology and composition of the samples were characterized through field emission scanning electron microscope (FE-SEM) with affiliated energy dispersive spectrometer (EDS), X-ray diffractometer (XRD), and Fourier infrared spectrometer (FTIR) and X-ray photoelectron spectrometer (XPS) as well. Potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and hydrogen evolution experiments were employed to evaluate the corrosion behavior of the samples. Atomic absorption spectrophotometer was used to measure Cu elemental content of different immersion periods. Cytocompatibility and antibacterial performance of the coatings were probed using in vitro cytotoxicity tests (MTT assay), live/dead cell staining and plate counting method. The results showed that the obtained (Ca-P/SCC) Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Authors.) |
| Databáze: | MEDLINE |
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