A novel system based on artificial intelligence for predicting blastocyst viability and visualizing the explanation.
| Autor: | Enatsu N; Hanabusa Women's Clinic Kobe Hyogo Japan., Miyatsuka I; NextGeM inc. Tokyo Japan., An LM; NextGeM inc. Tokyo Japan., Inubushi M; Hanabusa Women's Clinic Kobe Hyogo Japan., Enatsu K; Hanabusa Women's Clinic Kobe Hyogo Japan., Otsuki J; Hanabusa Women's Clinic Kobe Hyogo Japan.; Assisted Reproductive Technology Center Okayama University Okayama Japan., Iwasaki T; Hanabusa Women's Clinic Kobe Hyogo Japan., Kokeguchi S; Hanabusa Women's Clinic Kobe Hyogo Japan., Shiotani M; Hanabusa Women's Clinic Kobe Hyogo Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Reproductive medicine and biology [Reprod Med Biol] 2022 Feb 07; Vol. 21 (1), pp. e12443. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022). |
| DOI: | 10.1002/rmb2.12443 |
| Abstrakt: | Purpose: The purpose of the study was to invent and evaluate the novel artificial intelligence (AI) system named Fertility image Testing Through Embryo (FiTTE) for predicting blastocyst viability and visualizing the explanations via gradient-based localization. Methods: The authors retrospectively analyzed 19 342 static blastocyst images with related inspection histories from 9961 infertile patients who underwent in vitro fertilization. Among these data, 17 984 cycles of single-blastocyst transfer were used for training, and data from 1358 cycles were used for testing purposes. Results: The prediction accuracy for clinical pregnancy achieved by a control model using conventional Gardner scoring system was 59.8%, and area under the curve (AUC) was 0.62. FiTTE improved the prediction accuracy by using blastocyst images to 62.7% and AUC of 0.68. Additionally, the accuracy achieved by an ensemble model using image plus clinical data was 65.2% and AUC was 0.71, representing an improvement in prediction accuracy. The visualization algorithm showed brighter colors with blastocysts that resulted in clinical pregnancy. Conclusions: The authors invented the novel AI system, FiTTE, which could provide more precise prediction of the probability of clinical pregnancy using blastocyst images secondary to single embryo transfer than the conventional Gardner scoring assessments. FiTTE could also provide explanation of AI prediction using colored blastocyst images. Competing Interests: This study was funded in part by the Kobe Medical Industry Development Project, which is a public grant providing support in the form of research materials. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Isao Miyatsuka and Le My An are employees of NextGem Inc. The equipment and programs have been jointly provided by NextGem Inc. (© 2022 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.) |
| Databáze: | MEDLINE |
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