Additively manufactured metallic biomaterials.

Autor:	Davoodi E; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.; Department of Bioengineering, University of California, Los Angeles, California 90095, United States.; California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States.; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Montazerian H; Department of Bioengineering, University of California, Los Angeles, California 90095, United States.; California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States.; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Mirhakimi AS; Department of Mechanical Engineering, Isfahan University of Technology, Isfahan, Isfahan 84156-83111, Iran., Zhianmanesh M; School of Biomedical Engineering, University of Sydney, Sydney, New South Wales 2006, Australia., Ibhadode O; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Shahabad SI; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Esmaeilizadeh R; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Sarikhani E; Department of Nanoengineering, Jacobs School of Engineering, University of California, San Diego, California 92093, United States., Toorandaz S; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada., Sarabi SA; Mechanical and Aerospace Engineering Department, University of California, Los Angeles, California 90095, United States., Nasiri R; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Zhu Y; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Kadkhodapour J; Department of Mechanical Engineering, Shahid Rajaee Teacher Training University, Tehran, Tehran 16785-163, Iran.; Institute for Materials Testing, Materials Science and Strength of Materials, University of Stuttgart, Stuttgart 70569, Germany., Li B; Department of Manufacturing Systems Engineering and Management, California State University, Northridge, California 91330, United States.; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Khademhosseini A; Terasaki Institute for Biomedical Innovation, Los Angeles, California 90024, United States., Toyserkani E; Multi-Scale Additive Manufacturing (MSAM) Laboratory, Mechanical and Mechatronics Engineering Department, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Jazyk:	angličtina
Zdroj:	Bioactive materials [Bioact Mater] 2021 Dec 30; Vol. 15, pp. 214-249. Date of Electronic Publication: 2021 Dec 30 (Print Publication: 2022).
DOI:	10.1016/j.bioactmat.2021.12.027
Abstrakt:	Metal additive manufacturing (AM) has led to an evolution in the design and fabrication of hard tissue substitutes, enabling personalized implants to address each patient's specific needs. In addition, internal pore architectures integrated within additively manufactured scaffolds, have provided an opportunity to further develop and engineer functional implants for better tissue integration, and long-term durability. In this review, the latest advances in different aspects of the design and manufacturing of additively manufactured metallic biomaterials are highlighted. After introducing metal AM processes, biocompatible metals adapted for integration with AM machines are presented. Then, we elaborate on the tools and approaches undertaken for the design of porous scaffold with engineered internal architecture including, topology optimization techniques, as well as unit cell patterns based on lattice networks, and triply periodic minimal surface. Here, the new possibilities brought by the functionally gradient porous structures to meet the conflicting scaffold design requirements are thoroughly discussed. Subsequently, the design constraints and physical characteristics of the additively manufactured constructs are reviewed in terms of input parameters such as design features and AM processing parameters. We assess the proposed applications of additively manufactured implants for regeneration of different tissue types and the efforts made towards their clinical translation. Finally, we conclude the review with the emerging directions and perspectives for further development of AM in the medical industry. Competing Interests: None. (© 2021 The Authors.)
Databáze:	MEDLINE
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