Absolute band neutrophils count is a predictor of overall survival in advanced uterine cervical cancer.

Autor: Nomelini RS; Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, UFTM Federal University of Triângulo Mineiro, Av. Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil. rosekeila@terra.com.br., Mota SDS; Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, UFTM Federal University of Triângulo Mineiro, Av. Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil., Murta EFC; Research Institute of Oncology (IPON)/Department of Gynecology and Obstetrics, UFTM Federal University of Triângulo Mineiro, Av. Getúlio Guaritá, s/n, Bairro Abadia, Uberaba, MG, 38025-440, Brazil.
Jazyk: angličtina
Zdroj: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2022 Nov; Vol. 306 (5), pp. 1697-1701. Date of Electronic Publication: 2022 Apr 07.
DOI: 10.1007/s00404-022-06545-w
Abstrakt: Purpose: Neutrophils play a role during the oncogenic process, and their count can be a prognostic marker. The objective was to evaluate the association of band and segmented neutrophils with prognostic factors, overall survival, and disease-free survival in advanced uterine cervical cancer (IIB to IVB staging).
Methods: This study evaluated 88 patients diagnosed with uterine cervical cancer staging IIB to IVB. The recorded data from medical records were age, parity, staging, histological type, absolute count of total neutrophils, band neutrophils and segmented neutrophils, disease-free survival, and overall survival. Receiver-operating characteristic (ROC) curve was used to obtain the area under the curve (AUC) and determine the best cut-off values for each parameter. Survival was verified by the Kaplan-Meier method, and multivariate analysis was performed by Cox regression. The level of significance was ≤ 0.05.
Results: Regarding the total neutrophils, band, and segmented neutrophils count, a cut-off value of 6187/mm 3 , 273 mm 3 and 6062/mm 3 were found, respectively. Overall survival was shorter in patients with total neutrophils greater than 6187/mm 3 (p = 0.012), band neutrophils greater than 273/mm 3 (p = 0.001), and segmented neutrophils greater than 6062/mm 3 (p = 0.013). After multivariate analysis considering the two types of neutrophils, only band neutrophils greater than 273/mm 3 remained as an independent factor for shorter overall survival.
Conclusion: The absolute count of band neutrophils greater than 273/mm 3 was a potential predictor of shorter overall survival in women with invasive cervical cancer. This count can be of great clinical use, in addition to being inexpensive, less invasive, and easy to perform.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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