Median preoptic GABA and glutamate neurons exert differential control over sleep behavior.
| Autor: | Machado NLS; Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA., Todd WD; Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA; Department of Zoology and Physiology, Program in Neuroscience, University of Wyoming, Laramie, WY 82071, USA., Kaur S; Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA., Saper CB; Department of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: csaper@bidmc.harvard.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2022 May 09; Vol. 32 (9), pp. 2011-2021.e3. Date of Electronic Publication: 2022 Apr 05. |
| DOI: | 10.1016/j.cub.2022.03.039 |
| Abstrakt: | Previous studies suggest that the median preoptic nucleus (MnPO) of the hypothalamus plays an important role in regulating the wake-sleep cycle and, in particular, homeostatic sleep drive. However, the precise cellular phenotypes, targets, and central mechanisms by which the MnPO neurons regulate the wake-sleep cycle remain unknown. Both excitatory and inhibitory MnPO neurons innervate brain regions implicated in sleep promotion and maintenance, suggesting that both cell types may participate in sleep control. Using genetically targeted approaches, we investigated the role of the MnPO GABAergic (MnPO Vgat ) and glutamatergic (MnPO Vglut2 ) neurons in modulating wake-sleep behavior of mice. We found that both neuron populations differentially participate in wake-sleep control, with MnPO Vgat neurons being involved in sleep homeostasis and MnPO Vglut2 neurons facilitating sleep during allostatic (stressful) challenges. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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