Two Distinct Illnesses Consistent With MIS-C in a Pediatric Patient.

Autor:	Hancock WC; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Green AM; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee.; St. Jude Children's Research Hospital, Memphis., Creel C; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Moyen S; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Collins KP; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Pishko SD; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Finkel TH; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee., Bagga B; University of Tennessee Health Science Center, Memphis, Tennessee.; Le Bonheur Children's Hospital, Memphis, Tennessee.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2022 May 01; Vol. 149 (5).
DOI:	10.1542/peds.2021-053123
Abstrakt:	Multisystem inflammatory syndrome in children (MIS-C) is a severe inflammatory response described in children after infection with severe acute respiratory syndrome coronavirus 2. We present a case of a 9-year-old African American boy with 2 distinct illnesses that were both consistent with MIS-C. He first presented in the early stages of our understanding of MIS-C with predominantly neurologic and gastrointestinal symptoms and demonstrated elevated inflammatory markers consistent with MIS-C. He was treated with intravenous immunoglobulin with complete resolution of signs and symptoms. After 7 months of good health, he returned with a second, distinct illness characterized by fever, rash, gastrointestinal symptoms, and elevated inflammatory markers that met the criteria for MIS-C. In addition, we identified new dilatation of the left anterior descending coronary artery. He improved rapidly after treatment with intravenous immunoglobulin, aspirin, and steroids. Our report highlights the need to achieve a better understanding of this entity's pathogenesis and clinical course and to improve anticipatory guidance for children with MIS-C. (Copyright © 2022 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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