| Autor: |
Kumar C; Natural Products and Analytical Chemistry Lab, Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India., Akhter S; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Department of Biotechnology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India., Satti NK; Natural Products and Analytical Chemistry Lab, Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Gupta VK; Department of Physics, University of Jammu, Jammu, India., Meena SR; Genetic Resource and Agrotech Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India., Vishwakarma R, Hassan QP; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.; Department of Biotechnology, CSIR-Indian Institute of Integrative Medicine, Srinagar, India., Verma MK; Natural Products and Analytical Chemistry Lab, Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India. |
| Abstrakt: |
In the present study, we report herein the isolation of cadinane-type sesquiterpenoid, tatarinowin A (ACH-6), and pentadecanoic acid (ACH-8) from petroleum ether extract of rhizome of Acorus calamus L. (Acoraceae) along with 6 other known compounds in this species. It is pertinent to mention here that this is the first report to stain these compounds in which dereplication approach based on GC-MS was applied to target unknown compounds ACH-6 and ACH-8 in A. calamus L. Derelpication approaches based on GC-MS is very useful technique in the area of drug discovery and have eminence potential to identify known and unknown compounds present in extracts of medicinal important plants. This technique can be used to expedite the process of purification of unknown compounds from different matrixes. The isolated compounds were identified with the help of inbuilt library search which reveals the presence of 17 known and 4 unknown compounds. Further, the structure elucidation of all isolated compounds was done using spectroscopy techniques. Also, the structure of ACH-6 was further confirmed by using the single-crystal X-ray diffraction technique. |
