Use of Popular Opinion Leader Models to Disseminate Information About Clinical Trials to Black Individuals With Lupus in Two US Cities.

Autor: Arneson LC; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Taber KA; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Williams JN; Emory University School of Medicine, Atlanta, Georgia., Ulysse SN; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Erickson DL; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Chmiel JS; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Milaeger H; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Freeman E; Center for Community Health Education Research and Service, Boston, Massachusetts., Canessa P; Illinois Public Health Association, Springfield, Illinois., Song J; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Chung AH; Northwestern University Feinberg School of Medicine, Chicago, Illinois., Feldman CH; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Ramsey-Goldman R; Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Jazyk: angličtina
Zdroj: Arthritis care & research [Arthritis Care Res (Hoboken)] 2023 Jan; Vol. 75 (1), pp. 44-52. Date of Electronic Publication: 2022 Aug 23.
DOI: 10.1002/acr.24889
Abstrakt: Objective: Clinical trials for systemic lupus erythematosus ("lupus") under enroll Black individuals despite higher disease prevalence, morbidity, and mortality among Black compared to White individuals. To begin to address this disparity, we leveraged community-academic partnerships in 2 US cities (Boston and Chicago) to train popular opinion leaders (POLs) to disseminate information about clinical trials in predominantly Black communities.
Methods: The team of community and academic partners collaboratively developed a 5-module curriculum about clinical trials, barriers, facilitators, and structural racism in research. We enrolled POLs in Boston and Chicago to participate virtually in the curriculum and assessed knowledge gained by comparing pre- and post-test scores. We described the POLs' ability to disseminate information about clinical trials through their communities.
Results: We enrolled 19 POLs in Boston and 16 in Chicago; overall, 71% reported a lupus diagnosis, 94% were female, and 80% self-identified as Black or African American. The program was adapted to virtual formats due to the COVID-19 pandemic. POLs demonstrated significant improvement comparing pre/post scores for the conduct of clinical trials and history of racism in clinical research. Fifteen POLs (43%) reported their dissemination of information about clinical trials. Information reached 425 community members in Boston (90% virtually) and 1,887 in Chicago (95% virtually).
Conclusion: By leveraging community-academic partnerships, we developed and implemented a curriculum to promote familiarity with clinical trials, leading to information dissemination by POLs in predominantly Black communities that are underrepresented in lupus clinical trials. The program successfully transitioned to a virtual model during the COVID-19 pandemic.
(© 2022 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
Databáze: MEDLINE
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