Aspirin improves transplant-free survival after TIPS implantation in patients with refractory ascites: a retrospective multicentre cohort study.

Autor: Seifert LL; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany. leonlouis.seifert@ukmuenster.de., Schindler P; Clinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany., Sturm L; Department of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany., Gu W; Department of Internal Medicine 1, University Hospital Frankfurt, 60596, Frankfurt, Germany., Seifert QE; Georg-August University of Goettingen, 37073, Goettingen, Germany., Weller JF; Department of Hematology, University Hospital Tuebingen, 72076, Tuebingen, Germany., Jansen C; Department of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany., Praktiknjo M; Department of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany., Meyer C; Department of Radiology, University Hospital Bonn, 53127, Bonn, Germany., Schoster M; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany., Wilms C; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany., Maschmeier M; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany., Schmidt HH; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany., Masthoff M; Clinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany., Köhler M; Clinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany., Schultheiss M; Department of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany., Huber JP; Department of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany., Bettinger D; Department of Medicine II, Medical Center University of Freiburg, University of Freiburg, 79106, Freiburg, Germany., Trebicka J; Department of Internal Medicine 1, University Hospital Frankfurt, 60596, Frankfurt, Germany., Wildgruber M; Clinic for Radiology, University Hospital Muenster, 48149, Muenster, Germany.; Department of Radiology, University Hospital LMU Munich, 81377, Munich, Germany., Heinzow H; Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, Infectiology, University Hospital Muenster, 48149, Muenster, Germany.; Department of Internal Medicine I, Krankenhaus der Barmherzigen Brüder, 54292, Trier, Germany.
Jazyk: angličtina
Zdroj: Hepatology international [Hepatol Int] 2022 Jun; Vol. 16 (3), pp. 658-668. Date of Electronic Publication: 2022 Apr 05.
DOI: 10.1007/s12072-022-10330-x
Abstrakt: Background and Aims: Transjugular intrahepatic portosystemic shunt (TIPS) implantation is an established procedure to treat portal hypertension. Impact of administration of aspirin on transplant-free survival after TIPS remains unknown.
Methods: A multicenter retrospective analysis including patients with TIPS implantation between 2011 and 2018 at three tertiary German Liver Centers was performed. N = 583 patients were included. Survival analysis was performed in a matched cohort after propensity score matching. Patients were grouped according to whether aspirin was (PSM-aspirin-cohort) or was not (PSM-no-aspirin-cohort) administered after TIPS. Primary endpoint of the study was transplant-free survival at 12 months after TIPS.
Results: Aspirin improved transplant-free survival 12 months after TIPS with 90.7% transplant-free survival compared to 80.0% (p = 0.001) after PSM. Separated by TIPS indication, aspirin did improve transplant-free survival in patients with refractory ascites significantly (89.6% vs. 70.6% transplant-free survival, p < 0.001), while no significant effect was observed in patients with refractory variceal bleeding (91.1% vs. 92.2% transplant-free survival, p = 0.797).
Conclusion: This retrospective multicenter study provides first data indicating a beneficial effect of aspirin on transplant-free survival after TIPS implantation in patients with refractory ascites.
(© 2022. The Author(s).)
Databáze: MEDLINE
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