Dietary curcumin nanoparticles promoted the performance, antioxidant activity, and humoral immunity, and modulated the hepatic and intestinal histology of Nile tilapia fingerlings.

Autor: Abdel-Tawwab M; Department of Fish Biology and Ecology, Central Laboratory for Aquaculture Research, Agriculture Research Center, Abbassa, Abo-Hammad, Sharqia, Egypt. mohsentawwab@arc.sci.eg., Eissa EH; Mariculture Research Center, Arish University, El-Arish, Egypt., Tawfik WA; Holding Co. for Biological Products and Vaccines, Giza, Egypt.; Naqaa Nanotechnology Network NNN, Giza, Egypt., Abd Elnabi HE; Department of Fish Resources and Aquaculture, Faculty of Environmental Agricultural Sciences, Arish University, El-Arish, Egypt., Saadony S; Department of Animal Production and Fish Resources, Faculty of Agriculture, Suez Canal University, Ismailia, Egypt., Bazina WK; National Institute of Oceanography and Fisheries, Cairo, Egypt., Ahmed RA; Department of Aquaculture, Faculty of Fish and Fisheries Technology, Aswan University, Aswan, Egypt.
Jazyk: angličtina
Zdroj: Fish physiology and biochemistry [Fish Physiol Biochem] 2022 Jun; Vol. 48 (3), pp. 585-601. Date of Electronic Publication: 2022 Apr 05.
DOI: 10.1007/s10695-022-01066-4
Abstrakt: The current study investigated the effects of dietary curcumin nanoparticles (C-NPs) on the performance, hemato-biochemical profile, digestive enzymes activities, antioxidant status, humoral immunity, and liver and intestinal histology of Nile tilapia (Oreochromis niloticus). Fish (4.3 ± 0.5 g) were fed with diets enriched with 0.0 (control), 15, 30, 45, and 60 mg C-NPs/kg diet up to apparent satiety thrice a day for 60 days. The growth-stimulating effects of dietary C-NPs were significantly observed in terms of final weight, weight gain %, specific growth rate, and feed intake. Compared with the control group, serum amylase, lipase, and proteases activities of Nile tilapia significantly (P < 0.05) increased alongside the increase in dietary levels of C-NPs in a dose-dependent manner. The counts of red blood cells and white blood cells as well as hemoglobin and hematocrit levels of Nile tilapia fed with 30-60 mg C-NPs/kg diet were statistically (P < 0.05) higher than fish in the control group with no significant differences among them (P > 0.05). Moreover, lymphocytes and monocytes significantly (P > 0.05) increased; meanwhile neutrophils significantly (P > 0.05) decreased as C-NPs levels in diets increased. In a similar trend, antioxidant (malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase) and humoral immunity (lysozyme and total immunoglobulin) biomarkers were significantly higher in C-NPs-fed fish. Liver histology showed improvements in the cell architecture of fish fed with C-NPs containing diets up to 45 mg/kg diet. Compared with the control diet, feeding Nile tilapia with C-NPs diets resulted in a higher villi length/width and absorption area. According to the regression curves, the current study recommends using the dietary C-NP with optimum values of 45-55 mg/kg diet to improve the performance, digestive enzymes, antioxidant activities, and immunity response of Nile tilapia.
(© 2022. The Author(s).)
Databáze: MEDLINE
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