Seroprevalence of SARS-Cov-2 IgG antibodies in patients at a single center in Saudi Arabia.

Autor:	Mahallawi WH; From the Medical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia., Alsarani MA; From the Medical Services, Taibah University, Madinah, Saudi Arabia., Aljohani RH; From the Medical Services, Taibah University, Madinah, Saudi Arabia., Alluhaibi AA; From the Medical Services, Taibah University, Madinah, Saudi Arabia., Alamri TH; From the Medical Services, Taibah University, Madinah, Saudi Arabia., Ibrahim NA; From the Medical Laboratory Technology Department, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia., Mahallawi KH; From the General Directorate of Health Affairs, Rehabilitation Hospital, Ministry of Health, Madina, Saudi Arabia., Khabourd OF; From the Department of Medical Laboratory Services, Jordan University of Science and Technology, Irbid, Jordan.
Jazyk:	angličtina
Zdroj:	Annals of Saudi medicine [Ann Saudi Med] 2022 Mar-Apr; Vol. 42 (2), pp. 69-74. Date of Electronic Publication: 2022 Apr 07.
DOI:	10.5144/0256-4947.2022.69
Abstrakt:	Background: The coronavirus disease 2019 (COVID-19) pandemic has had a massive impact on public health as well as the economy. Understanding the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among undiagnosed individuals is important for developing an informed pandemic response. Objective: Investigate the prevalence of undiagnosed COVID-19 disease. Design: Cross-sectional. Setting: Tertiary care center in Madinah, Saudi Arabia. Subjects and Methods: All participants were on follow-up visits to various clinics and had not been previously diagnosed with COVID-19. Enzyme-linked immunosorbent assay was used to specifically assess the anti-spike IgG antibody seropositivity in serum samples. We associated the seropositivity rates of the participants with age, body mass index (BMI), nationality, blood groups, and sex with uni- and multivariate analyses. Main Outcome Measures: Seropositivity for IgG anti-spike antibodies against SARS-CoV-2. Sample Size and Characteristics: 527 subjects, with a median (interquartile percentiles) age of the 527 subjects was 34 (24-41). Results: Of the 527 samples, about one-fourth (n=124, 23.5%) were positive for anti-spike IgG antibody against SARS CoV-2. Age was associated with anti-spike IgG antibody positivity ( P <.002). Participants >30 years were more likely to be seropositive (28-29%) than younger participants (15.4%). Additionally, seropositivity was associated with female gender ( P <.001) and a higher BMI ( P <.006). In the multivariate logistic regression, age >30, female gender and BMI >40 were associated with seropositivity. Conclusion: The percentage of seropositive individuals reflects the high level of undiagnosed COVID-19 patients among the population. Our results will help in a better evaluation of the public health measures applied during the COVID-19 pandemic and any future public health crises. Limitations: Sample size was small, single-center study and no rural areas were included. Conflict of Interest: None.
Databáze:	MEDLINE
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