Simultaneous visualization of multiple radionuclides in vivo.

Autor: Yagishita A; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan. yagisitta@g.ecc.u-tokyo.ac.jp.; Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan. yagisitta@g.ecc.u-tokyo.ac.jp., Takeda S; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan. shinichiro.takeda@ipmu.jp., Katsuragawa M; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan., Kawamura T; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Department of Physics, The University of Tokyo, Tokyo, Japan., Matsumura H; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan., Orita T; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan., Umeda IO; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan., Yabu G; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Department of Physics, The University of Tokyo, Tokyo, Japan., Caradonna P; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan., Takahashi T; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Department of Physics, The University of Tokyo, Tokyo, Japan., Watanabe S; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Institute of Space and Astronautical Science (ISAS)/JAXA, Sagamihara, Japan., Kanayama Y; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan., Mizuma H; Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), The University of Tokyo, Kashiwa, Japan.; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan., Ohnuki K; Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan., Fujii H; Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2022 May; Vol. 6 (5), pp. 640-647. Date of Electronic Publication: 2022 Apr 04.
DOI: 10.1038/s41551-022-00866-6
Abstrakt: The insufficient energy and spatial resolutions of radionuclide imaging with conventional scintillation detectors restrict the visualization of multiple radionuclides and of microstructures in tissue. Here we report the development and performance of an imaging system equipped with a cadmium telluride diode detector that achieves an energy resolution of 1.7% at 140 keV and a spatial resolution of 250 μm. The combination of high-resolution spectra fitted to an X-ray analysis model of the emission lines of the radionuclides in a chosen energy band allowed us to accurately determine individual radiation activities from three radionuclides to simultaneously visualize thyroid tissue (via intravenously administered iodine-125), mandibular lymph nodes (via the intramuscular injection of indium-111) and parotid lymph nodes (via a subcutaneous injection of technetium-99m) in mice. Multi-radionuclide imaging may find advantageous applications in biomedical imaging.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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