Proposal of a population wide genome-based testing for Covid-19.
| Autor: | Lehrach H; Alacris Theranostics GmbH, Berlin, Germany. lehrach@molgen.mpg.de.; Max Planck Institute for Molecular Genetics, Ihnestraße 63, 14195, Berlin, Germany. lehrach@molgen.mpg.de., Curtis J; Alacris Theranostics GmbH, Berlin, Germany., Lange B; Alacris Theranostics GmbH, Berlin, Germany., Ogilvie LA; Alacris Theranostics GmbH, Berlin, Germany., Gauss R; State Sanitary Directorate, City Government, Vienna, Austria., Steininger C; Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna, Vienna, Austria.; LEAD Horizon, Vienna, Austria., Scholz E; University of Wuppertal, Wuppertal, Germany., Kreck M; University of Bonn, Bonn, Germany.; University of Frankfurt, Frankfurt, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Scientific reports [Sci Rep] 2022 Apr 04; Vol. 12 (1), pp. 5618. Date of Electronic Publication: 2022 Apr 04. |
| DOI: | 10.1038/s41598-022-08934-2 |
| Abstrakt: | Our lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel tool for controlling the COVID-19 pandemic. The key element is a method for a population-scale PCR-based testing, applied on a systematic and repeated basis. For this we have developed a low cost, highly sensitive virus-genome-based test. Using Germany as an example, we demonstrate by using a mathematical model, how useful this strategy could have been in controlling the pandemic. We show using real-world examples how this might be implemented on a mass scale and discuss the feasibility of this approach. (© 2022. The Author(s).) |
| Databáze: | MEDLINE |
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