SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress.

Autor: Zayed A; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Baranowski C; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Compagnion AC; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Vernochet C; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Karaki S; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Cuttoli RD; Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC, Paris, France., Saint-Jour E; Sorbonne Université, Neuronal Signaling and Gene Regulation, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC, Paris, France., Bhattacharya S; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Marti F; Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC, Paris, France.; Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France., Vanhoutte P; Sorbonne Université, Neuronal Signaling and Gene Regulation, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC, Paris, France., Yaniv M; Developmental and Stem Cell Biology department, Pasteur Institute, Paris, France., Faure P; Sorbonne Université, Neurophysiology and Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, UPMC, Paris, France.; Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France., Barik J; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France.; Université Côte d'Azur, Nice, France.; Physiopathology of Neuronal Circuits and Behavior, IPMC, Valbonne, France., Amar L; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France., Tronche F; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France. francois.tronche@sorbonne-universite.fr., Parnaudeau S; Sorbonne Université, Gene Regulation and Adaptive Behaviors, Neuroscience Paris-Seine, IBPS. CNRS UMR8246, INSERM, Paris, France.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Apr 04; Vol. 13 (1), pp. 1807. Date of Electronic Publication: 2022 Apr 04.
DOI: 10.1038/s41467-022-29380-8
Abstrakt: Enduring behavioral changes upon stress exposure involve changes in gene expression sustained by epigenetic modifications in brain circuits, including the mesocorticolimbic pathway. Brahma (BRM) and Brahma Related Gene 1 (BRG1) are ATPase subunits of the SWI/SNF complexes involved in chromatin remodeling, a process essential to enduring plastic changes in gene expression. Here, we show that in mice, social defeat induces changes in BRG1 nuclear distribution. The inactivation of the Brg1/Smarca4 gene within dopamine-innervated regions or the constitutive inactivation of the Brm/Smarca2 gene leads to resilience to repeated social defeat and decreases the behavioral responses to cocaine without impacting midbrain dopamine neurons activity. Within striatal medium spiny neurons, Brg1 gene inactivation reduces the expression of stress- and cocaine-induced immediate early genes, increases levels of heterochromatin and at a global scale decreases chromatin accessibility. Altogether these data demonstrate the pivotal function of SWI/SNF complexes in behavioral and transcriptional adaptations to salient environmental challenges.
(© 2022. The Author(s).)
Databáze: MEDLINE
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