| Autor: |
Volz HP; Department of Psychotherapy and Psychosomatic Medicine, Hospital for Psychiatry, Werneck, Germany., Bartečků E; Department of Psychiatry, Masaryk University and University Hospital Brno, Brno, Czech Republic., Bartova L; Department of Psychiatry and Psychotherapy (Division of General Psychiatry), Medical University of Vienna, Vienna, Austria., Bessa J; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal., De Berardis D; NHS, Department of Mental Health, Psychiatric Service for Diagnosis and Treatment, Hospital 'G. Mazzini', Teramo, Italy., Dragasek J; First Department of Psychiatry, Pavol Jozef Šafárik University and University Hospital, Košice, Slovakia., Kozhuharov H; Department of Psychiatry, University Hospital, 'St. Marina', Varna, Bulgaria., Ladea M; University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania., Lazáry J; Nyírő Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary., Roca M; School of Medicine, Son Espases University Hospital, IUNICS/IDISBA, University of Balearic Islands, Palma de Mallorca, Spain., Usov G; Omsk State Medical University, Omsk, Russia., Wichniak A; Third Department of Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland., Godman B; Department of Pharmacoepidemiology, Strathclyde Institute of Pharmacy and Biomedical Sciences, Strathclyde University, Glasgow, UK.; School of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University, Pretoria, South Africa.; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, United Arab Emirates., Kasper S; Department of Psychiatry and Psychotherapy (Division of General Psychiatry), Medical University of Vienna, Vienna, Austria.; Center for Brain Research, Medical University of Vienna, Vienna, Austria. |
| Abstrakt: |
Objective: To discuss the impact of depression on work and how depression-related sick leave duration could be a potential indicator and outcome for measuring functionality in depression. Methods: Our review was based on a literature search and expert opinion that emerged during a virtual meeting of European psychiatrists that was convened to discuss this topic. Results: Current evidence demonstrates that depression-related sick leave duration is influenced by multiple disease-, patient- and work-related factors, together with societal attitudes towards depression and socioeconomic conditions. A wide variety of pharmacological and non-pharmacological treatments and work-based interventions are effective in reducing depression-related sick leave duration and/or facilitating return to work. Recent real-world evidence showed that patients treated with antidepressant monotherapy appear to recover their working life faster than those receiving combination therapy. Although depression-related sick leave duration was found to correlate with severity of depressive symptoms, it cannot be used alone as a viable marker for disease severity. Conclusions: Given its multifactorial nature, depression-related sick leave duration is not on its own a viable outcome measure of depression severity but could be used as a secondary outcome alongside more formal severity measures and may also represent a useful measure of functionality in depression. Key pointsDepression in the working population and depression-related sick leave have a profound economic impact on societyDepression-related sick leave duration is influenced by multiple disease-, patient- and work-related factors, together with societal attitudes towards depression and socioeconomic conditionsA wide variety of pharmacological and non-pharmacological treatments and work-based interventions have been shown to be effective in reducing depression-related sick leave duration and/or facilitating return to workIn terms of pharmacological intervention, recent real-world evidence has shown that patients treated with antidepressant monotherapy are able to recover their working life faster than those treated with combination therapyAlthough depression-related sick leave duration has been shown to correlate with severity of depressive symptoms, it is not a viable outcome measure of depression severity on its own, but could be used as secondary outcome alongside more formal clinician- and patient-rated severity measuresDepression-related sick leave duration may, however, represent a viable outcome for measuring functionality in depression. |
