Glomerular Disease in Temporal Association with SARS-CoV-2 Vaccination: A Series of 29 Cases.

Autor:	Caza TN; Arkana Laboratories, Little Rock, Arkansas., Cassol CA; Arkana Laboratories, Little Rock, Arkansas., Messias N; Arkana Laboratories, Little Rock, Arkansas., Hannoudi A; University of Michigan, Ann Arbor, Michigan., Haun RS; Arkana Laboratories, Little Rock, Arkansas., Walker PD; Arkana Laboratories, Little Rock, Arkansas., May RM; Arkana Laboratories, Little Rock, Arkansas., Seipp RM; DuPage Medical Group, Naperville, Illinois., Betchick EJ; Methodist LeBonheur Healthcare-Germantown, Germantown, Tennessee., Amin H; The Kidney Group of Memphis, Memphis, Tennessee., Ziadie MS; Memorial Regional Hospital, Miramar, Florida., Haderlie M; Iowa Kidney Institute, Bingham Memorial Hospital, Blackfoot, Idaho., Eduwu-Okwuwa J; Permian Nephrology Associates, Midland, Texas., Vancea I; Southern Colorado Nephrology Associates, Pueblo, Colorado., Seek M; Ocala Kidney Group, Ocala, Florida., Elashi EB; Firelands Physicians Group, Sandusky, Ohio., Shenoy G; Lee Kidney Center, Lehigh Acres, Florida., Khalillullah S; North Florida Nephrology Associates, Tallahassee, Florida., Flaxenburg JA; Pikes Peak Nephrology, Colorado Springs, Colorado., Brandt J; Division of Nephrology, University of New Mexico, Albuquerque, New Mexico., Diamond MJ; Nephrology Associates (Augusta), Augusta, Georgia., Frome A; Kidney Specialists of North Houston, Shenandoah, Texas., Kim EH; Kidney and Hypertension Specialists PLLC, Manassas, Virginia., Schlessinger G; Rocky Mountain Kidney Care, Lone Tree, Colorado., Ulozas E; Carle Nephrology, Urbana, Illinois., Weatherspoon JL; Southern Crescent Nephrology, Stockbridge, Georgia., Hoerschgen ET; Springfield Nephrology Associates, Springfield, Missouri., Fabian SL; Rocky Mountain Kidney Care, Aurora, Colorado., Bae SY; East Tennessee Nephrology, Knoxville, Tennessee., Iqbal B; Kidney Specialists of Southern Nevada, Las Vegas, Nevada., Chouhan KK; Iowa Kidney Physicians P.C., Des Moines, Iowa., Karam Z; Mercy Clinic Nephrology, Washington, Missouri., Henry JT; Renal Care Associates, Fort Smith, Arkansas., Larsen CP; Arkana Laboratories, Little Rock, Arkansas.
Jazyk:	angličtina
Zdroj:	Kidney360 [Kidney360] 2021 Sep 16; Vol. 2 (11), pp. 1770-1780. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).
DOI:	10.34067/KID.0005372021
Abstrakt:	Background: Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible individuals. Mass immunization against SARS-CoV-2 in the COVID-19 pandemic provides a unique opportunity to study vaccination-associated autoimmune kidney diseases. In the recent literature, there are several patient reports demonstrating a temporal association of SARS-CoV-2 immunization and kidney diseases. Methods: Here, we present a series of 29 cases of biopsy-proven glomerular disease in patients recently vaccinated against SARS-CoV-2 and identified patients who developed a new onset of IgA nephropathy, minimal change disease, membranous nephropathy, ANCA-associated GN, collapsing glomerulopathy, or diffuse lupus nephritis diagnosed on kidney biopsies postimmunization, as well as recurrent ANCA-associated GN. This included 28 cases of de novo GN within native kidney biopsies and one disease flare in an allograft. Results: The patients with collapsing glomerulopathy were of Black descent and had two APOL1 genomic risk alleles. A brief literature review of patient reports and small series is also provided to include all reported cases to date ( n =52). The incidence of induction of glomerular disease in response to SARS-CoV-2 immunization is unknown; however, there was no overall increase in incidence of glomerular disease when compared with the 2 years prior to the COVID-19 pandemic diagnosed on kidney biopsies in our practice. Conclusions: Glomerular disease to vaccination is rare, although it should be monitored as a potential adverse event. Competing Interests: J.T. Henry reports ownership interest in Fort Smith Regional Dialysis. G. Schlessinger reports consultancy agreements with Medtronic and ownership interest in US Renal Care. Z. Karam reports honoraria from Spherix. R.M. Seipp reports honoraria from M3 Global Research and Spherix Global Insights. P.D. Walker reports consultancy agreements with Apellis and Travere and honoraria from Apellis and Travere. All remaining authors have nothing to disclose. (Copyright © 2021 by the American Society of Nephrology.)
Databáze:	MEDLINE
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