Impact of IDH1 c.315C>T SNP on Outcomes in Acute Myeloid Leukemia: A Propensity Score-Adjusted Cohort Study.

Autor:	Corley EM; School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Mustafa Ali MK; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Alharthy H; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Kline KAF; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Sewell D; Translational Genomics Laboratory, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States., Law JY; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Lee ST; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Niyongere S; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Duong VH; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Baer MR; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States., Emadi A; Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Medicine, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.; Translational Genomics Laboratory, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2022 Mar 18; Vol. 12, pp. 804961. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022).
DOI:	10.3389/fonc.2022.804961
Abstrakt:	Acute myeloid leukemia (AML) is the common type of acute leukemia in adults. Definitive prognostic significance of variants of unknown significance lacks for many commonly mutated genes, including the isocitrate dehydrogenase 1 (IDH1) synonymous single nucleotide polymorphism (SNP) variant c.315C>T. In this retrospective cohort study of 248 AML patients at the University of Maryland Greenebaum Comprehensive Cancer Center, we show that the IDH1 c.315C>T SNP, previously reported to be associated with poor prognosis by other studies with conflicting data, does not confer worse prognosis, with a median overall survival (OS) of 17.1 months compared to 15.1 months for patients without this SNP (P=0.57). The lack of negative effect on prognosis by IDH1 SNP c.315C>T is consistent with the absence of amino acid alteration (p.Gly105Gly). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Corley, Mustafa Ali, Alharthy, Kline, Sewell, Law, Lee, Niyongere, Duong, Baer and Emadi.)
Databáze:	MEDLINE
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