Successful Use of Intravitreal Bevacizumab and Methotrexate in a Case of Neovascularization of the Iris and Pseudohypopyon Secondary to Recurrent Diffuse Large B-Cell Lymphoma.
| Autor: | Ahmed H; Ophthalmology, Loma Linda University Medical Center, Loma Linda, USA., James A; Ophthalmology, Loma Linda University Medical Center, Loma Linda, USA., Enghelberg M; Retina Service, Loma Linda University Eye Institute, Loma Linda, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Feb 24; Vol. 14 (2), pp. e22578. Date of Electronic Publication: 2022 Feb 24 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.22578 |
| Abstrakt: | In this case report, we aim to describe a rare case of recurrent diffuse large B-cell lymphoma (DLBCL) reportedly in remission presenting with primary anterior segment findings and use of intravitreal bevacizumab and methotrexate to treat the sequelae. The patient presented with hypopyon and neovascularization of the iris (NVI). Anterior chamber studies including flow cytometry and imaging revealed DLBCL recurrence with central nervous system (CNS) involvement. Over one month, he was treated with one intravitreal injection of bevacizumab, repeat injections of methotrexate, and systemic therapies with the resolution of ocular symptoms but persistent systemic disease. This case highlights the utility of anterior chamber paracentesis in diagnosis and intravitreal bevacizumab and methotrexate in the treatment for anterior segment manifestations of intraocular lymphoma (IOL). Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Ahmed et al.) |
| Databáze: | MEDLINE |
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