Restless Legs Syndrome Prevalence and Clinical Correlates Among Psychiatric Inpatients: A Multicenter Study.

Autor:	Weber FC; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany., Danker-Hopfe H; Charité-Universitätsmedizin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Competence Center of Sleep Medicine Berlin, Berlin, Germany., Dogan-Sander E; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany., Frase L; Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg - Faculty of Medicine, University of Freiburg, Freiburg, Germany., Hansel A; Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg - Faculty of Medicine, University of Freiburg, Freiburg, Germany., Mauche N; Department of Psychiatry and Psychotherapy, University Leipzig, Medical Faculty, Leipzig, Germany., Mikutta C; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.; Privatklinik Meiringen, Meiringen, Switzerland., Nemeth D; Department of Psychiatry and Psychotherapy, Paracelsus Medical University, Nuremberg, Germany., Richter K; Department of Psychiatry and Psychotherapy, Paracelsus Medical University, Nuremberg, Germany., Schilling C; Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sebestova M; Privatklinik Meiringen, Meiringen, Switzerland., Spath MM; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Nissen C; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Wetter TC; Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2022 Mar 14; Vol. 13, pp. 846165. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).
DOI:	10.3389/fpsyt.2022.846165
Abstrakt:	Background: There are only limited reports on the prevalence of restless legs syndrome (RLS) in patients with psychiatric disorders. The present study aimed to evaluate the prevalence and clinical correlates in psychiatric inpatients in Germany and Switzerland. Methods: This is a multicenter cross-sectional study of psychiatric inpatients with an age above 18 years that were diagnosed and evaluated face-to-face using the International RLS Study Group criteria (IRLSSG) and the International RLS severity scale (IRLS). In addition to sociodemographic and biometric data, sleep quality and mood were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the Patient Health Questionnaire (PHQ-9). In addition to univariate statistics used to describe and statistically analyze differences in variables of interest between patients with and without RLS, a logistic model was employed to identify predictors for the occurrence of RLS. Results: The prevalence of RLS in a sample of 317 psychiatric inpatients was 16.4%, and 76.9% of these were diagnosed with RLS for the first time. RLS severity was moderate to severe (IRLS ± SD: 20.3 ± 8.4). The prevalences in women ( p = 0.0036) and in first-degree relatives with RLS ( p = 0.0108) as well as the body mass index (BMI, p = 0.0161) were significantly higher among patients with RLS, while alcohol consumption was significantly lower in the RLS group. With the exception of atypical antipsychotics, treatment with psychotropic drugs was not associated with RLS symptoms. Regarding subjective sleep quality and mood, scores of the PSQI ( p = 0.0007), ISI ( p = 0.0003), and ESS ( p = 0.0005) were higher in patients with RLS, while PHQ-9 scores were not different. A logistic regression analysis identified gender (OR 2.67; 95% CI [1.25; 5.72]), first-degree relatives with RLS (OR 3.29; 95% CI [1.11; 9.73], ESS score (OR 1.09; 95% CI [1.01; 1.17]), and rare alcohol consumption (OR 0.45; 95% CI [0.22; 0.94] as predictors for RLS. Conclusions: Clinically significant RLS had a high prevalence in psychiatric patients. RLS was associated with higher BMI, impaired sleep quality, and lower alcohol consumption. A systematic assessment of restless legs symptoms might contribute to improve the treatment of psychiatric patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Weber, Danker-Hopfe, Dogan-Sander, Frase, Hansel, Mauche, Mikutta, Nemeth, Richter, Schilling, Sebestova, Spath, Nissen and Wetter.)
Databáze:	MEDLINE
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