COVCOG 2: Cognitive and Memory Deficits in Long COVID: A Second Publication From the COVID and Cognition Study.

Autor:	Guo P; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Benito Ballesteros A; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Yeung SP; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Liu R; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Saha A; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Curtis L; School of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom., Kaser M; Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom., Haggard MP; Department of Psychology, University of Cambridge, Cambridge, United Kingdom., Cheke LG; Department of Psychology, University of Cambridge, Cambridge, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Mar 17; Vol. 14, pp. 804937. Date of Electronic Publication: 2022 Mar 17 (Print Publication: 2022).
DOI:	10.3389/fnagi.2022.804937
Abstrakt:	COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been often characterized as a respiratory disease. However, it is increasingly being understood as an infection that impacts multiple systems, and many patients report neurological symptoms. Indeed, there is accumulating evidence for neural damage in some individuals, with recent studies suggesting loss of gray matter in multiple regions, particularly in the left hemisphere. There are several mechanisms by which the COVID-19 infection may lead to neurological symptoms and structural and functional changes in the brain, and cognitive problems are one of the most commonly reported symptoms in those experiencing Long COVID - the chronic illness following the COVID-19 infection that affects between 10 and 25% of patients. However, there is yet little research testing cognition in Long COVID. The COVID and Cognition Study is a cross-sectional/longitudinal study aiming to understand cognitive problems in Long COVID. The first paper from the study explored the characteristics of our sample of 181 individuals who had experienced the COVID-19 infection, and 185 who had not, and the factors that predicted ongoing symptoms and self-reported cognitive deficits. In this second paper from the study, we assess this sample on tests of memory, language, and executive function. We hypothesize that performance on "objective" cognitive tests will reflect self-reported cognitive symptoms. We further hypothesize that some symptom profiles may be more predictive of cognitive performance than others, perhaps giving some information about the mechanism. We found a consistent pattern of memory deficits in those that had experienced the COVID-19 infection, with deficits increasing with the severity of self-reported ongoing symptoms. Fatigue/Mixed symptoms during the initial illness and ongoing neurological symptoms were predictive of cognitive performance. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Guo, Benito Ballesteros, Yeung, Liu, Saha, Curtis, Kaser, Haggard and Cheke.)
Databáze:	MEDLINE
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