Acute urticaria in children: course of the disease, features of skin microbiome.

Autor: Orlova E; Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia., Smirnova L; Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia., Nesvizhsky Y; Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia., Kosenkov D; Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia., Zykova E; Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.
Jazyk: angličtina
Zdroj: Postepy dermatologii i alergologii [Postepy Dermatol Alergol] 2022 Feb; Vol. 39 (1), pp. 164-170. Date of Electronic Publication: 2022 Feb 28.
DOI: 10.5114/ada.2022.113808
Abstrakt: Introduction: Quantitative and qualitative changes in the microbiome of the skin affect the emergence and course of allergic diseases, in particular, of acute urticaria.
Aim: To investigate the taxonomic composition of the skin microbiota in children with acute urticaria and to study its effect on the course of the disease.
Material and Methods: In total, 75 children with diagnosed acute urticaria at the age of 7--14 years were examined. The average age of children was 10.83 ±0.95, of which 44 (58.7%) were boys, and 31 (41.3%) were girls. The control group consisted of 30 virtually healthy children of the appropriate age, of whom 16 (53.3%) were boys, and 13 (46.7%) were girls.
Results: Regardless of the severity of the disease, the examined children suffering from acute urticaria had sensitization in history with a significant prevalence of food sensitization ( p < 0.05). The occurrence of a severe episode of acute urticaria is associated with allergens of drug origin in 52.6% of cases and the action of unidentified triggers in 47.4% of cases. In children with acute urticaria, S. epidermidis, S. aureus , bacteria of the genus Peptococcus , and Peptostreptococcus dominated on a non-affected skin area, while for the affected skin area, the Propionibacterium, S. aureus, S. epidermidis , bacteria of the genus Peptococcus, Propionibacterium , and Peptostreptococcus were denoted as dominating.
Conclusions: High frequency of S. aureus detection on affected and non- affected skin areas in children with acute urticaria is a predictor of the disease severity.
Competing Interests: The authors declare no conflict of interest.
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Databáze: MEDLINE
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