Clinical Characteristics and Long-Term Outcomes of Patients With Differing Haemoglobin Levels Undergoing Semi-Urgent and Elective Percutaneous Coronary Intervention in an Asian Population.

Autor: Soh RY; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Sia CH; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Djohan AH; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Lau RH; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Ho PY; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Neo JW; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Ho JS; School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Sim HW; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Yeo TC; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Tan HC; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Chan MY; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Loh JP; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Mar 18; Vol. 9, pp. 687555. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022).
DOI: 10.3389/fcvm.2022.687555
Abstrakt: Introduction: This study aimed to investigate the impact of anaemia on long-term clinical outcomes in patients who underwent semi-urgent and elective percutaneous coronary intervention (PCI) in an Asian population. Although the effects of anaemia on outcomes in Asian patients are well studied for acute coronary syndrome, its impact on Asian patients undergoing semi-urgent and elective PCI is unclear.
Methods: This was a retrospective cohort study of patients who underwent semi-urgent and elective PCI from January 1, 2014, to December 31, 2015, at a tertiary academic centre. A total of 1,685 patients were included. They were stratified into three groups: normal (≥12 g/dL), intermediate (10-11.9 g/dL), and low (<10 g/dL) haemoglobin levels. Demographics, risk factors, and end-points including the 5-point major adverse cardiac and cerebrovascular events (MACCE) (all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation), cardiovascular death, and bleeding events were analysed.
Results: Patients in intermediate and low haemoglobin level groups were older with more comorbidities. Compared to the normal haemoglobin level group, low haemoglobin level group patients were associated with an increased risk of composite endpoints of all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation [adjusted hazard ratio (aHR) 1.89, 95% confidence interval (CI):1.22, 2.92; p = 0.004]. This was driven by the increased risk of target lesions revascularisation observed in the low haemoglobin level group compared to the normal haemoglobin level group (aHR 17.74, 95% CI: 1.74, 180.80; p = 0.015). The patients in the low haemoglobin level group were also associated with a higher risk of bleeding events compared to the normal haemoglobin level group (aHR 7.18, 95% CI: 1.13, 45.40; p = 0.036).
Conclusion: In our Asian cohort, patients with anaemia undergoing PCI were associated with a higher comorbid burden. Despite adjustments for comorbidities, these patients had higher mortality and worse cardiovascular outcomes following contemporary PCI.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Soh, Sia, Djohan, Lau, Ho, Neo, Ho, Sim, Yeo, Tan, Chan and Loh.)
Databáze: MEDLINE