Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis.

Autor: Torequl Islam M; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Quispe C; Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile., Herrera-Bravo J; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Santiago, Chile.; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile., Rahaman MM; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Hossain R; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Sarkar C; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Raihan MA; Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh., Chowdhury MM; Department of Pharmacy, Southern University Bangladesh, Arefin Nagar 4210, Chattagram, Bangladesh., Uddin SJ; Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh., Shilpi JA; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Santiago, Chile., Marcelo de Castro E Sousa J; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina 64049-550, Brazil., Melo-Cavalcante AAC; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina 64049-550, Brazil., Mubarak MS; Department of Chemistry, The University of Jordan, Amman 11942, Jordan., Sharifi-Rad J; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2022 Mar 25; Vol. 2022, pp. 4787643. Date of Electronic Publication: 2022 Mar 25 (Print Publication: 2022).
DOI: 10.1155/2022/4787643
Abstrakt: Diterpenes and their derivatives have many biological activities, including anti-inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory-derived products have been demonstrated for antiarthritic activities. This study summarizes the literature about diterpenes and their derivatives acting against rheumatoid arthritis (RA) depending on the database reports until 31 August 2021. For this, we have conducted an extensive search in databases such as PubMed, Science Direct, Google Scholar, and Clinicaltrials.gov using specific relevant keywords. The search yielded 2708 published records, among which 48 have been included in this study. The findings offer several potential diterpenes and their derivatives as anti-RA in various test models. Among the diterpenes and their derivatives, andrographolide, triptolide, and tanshinone IIA have been found to exhibit anti-RA activity through diverse pathways. In addition, some important derivatives of triptolide and tanshinone IIA have also been shown to have anti-RA effects. Overall, findings suggest that these substances could reduce arthritis score, downregulate oxidative, proinflammatory, and inflammatory biomarkers, modulate various arthritis pathways, and improve joint destruction and clinical arthritic conditions, signs, symptoms, and physical functions in humans and numerous experimental animals, mainly through cytokine and chemokine as well as several physiological protein interaction pathways. Taken all together, diterpenes, diterpenoids, and their derivatives may be promising tools for RA management.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Muhammad Torequl Islam et al.)
Databáze: MEDLINE
Externí odkaz: