Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review.
| Autor: | González Cordero EM; Universidad Francisco de Vitoria, Madrid, Spain., Cuevas-Budhart MA; Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico., Pérez Morán D; Unidad de Investigación Epidemiológica y de Servicios de Salud, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico., Trejo Villeda MA; Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico., Gomez-Del-Pulgar Gª-Madrid M; Universidad Francisco de Vitoria, Madrid, Spain.; Centro Universitario Hygiea, Madrid, Spain. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 87 (2), pp. 519-528. |
| DOI: | 10.3233/JAD-215224 |
| Abstrakt: | Background: In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective: To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer's disease. Method: Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results: Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. Conclusion: The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic. |
| Databáze: | MEDLINE |
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