A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease.
| Autor: | Asad HN; Al Najaf Health Directorate, Higher Health Institute, Najaf, Iraq., Al-Hakeim HK; Department of Chemistry, College of Science, University of Kufa, Iraq., Moustafa SR; Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Iraq., Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.; School of Medicine, IMPACT Strategic Research Centre, Deakin University, VIC, 3220, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2023; Vol. 22 (2), pp. 191-206. |
| DOI: | 10.2174/1871527321666220401140747 |
| Abstrakt: | Background: End-stage renal disease (ESRD) is associated with fatigue and physiosomatic symptoms. Objective: The objective of this study is to delineate the associations between severity of fatigue and physio-somatic symptoms and glomerular filtration rate, inflammatory biomarkers, and Wnt/cateninpathway proteins. Methods: The Wnt-pathway related proteins β-catenin, Dickkopf-related protein 1 (DKK1), R-spondin- 1, and sclerostin were measured by ELISA technique in 60 ESRD patients and 30 controls. The Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale was used to assess the severity of FF symptoms. Results: ESRD is characterized by a significant increase in the total FF score, muscle tension, fatigue, sadness, sleep disorders, gastro-intestinal (GI) symptoms, and a flu-like malaise. The total-FF score was significantly correlated with serum levels of urea, creatinine, and copper (positively), and β-catenin, eGFR, hemoglobin, albumin, and zinc (inversely). The total-FF score was associated with the number of total dialysis and weekly dialysis sessions, and these dialysis characteristics were more important in predicting FF scores than eGFR measurements. Partial Least Squares analysis showed that the FF score comprised two factors that are differently associated with biomarkers: a) 43.0% of the variance in fatigue, GI symptoms, muscle tension, sadness, and insomnia is explained by hemoglobin, albumin, zinc, β-catenin, and R-spondin-1; and b) 22.3% of the variance in irritability, concentration and memory impairments by increased copper and cations/chloride ratio, and male sex. Conclusion: ESRD patients show high levels of fatigue and physio-somatic symptoms associated with hemodialysis and mediated by dialysis-induced changes in inflammatory pathways, the Wnt/catenin pathway, and copper. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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