| Autor: |
Silina EV; Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Stupin VA; Department of Hospital Surgery No. 1, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia., Abramov IS; Department of Hospital Surgery No. 1, N.I. Pirogov Russian National Research Medical University, 117997 Moscow, Russia., Bolevich SB; Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Deshpande G; Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570 015, India.; Department of Biochemisty, Karnatak University, Dharwad 580 003, India., Achar RR; Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570 015, India., Sinelnikova TG; Department of Human Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia. |
| Abstrakt: |
The aim of this study was to assess the patterns and pattern disruptions of free radical processes in patients with obstructive jaundice of various origins, and the severity of jaundice before and after decompression. Oxidative stress markers were determined in 128 patients with obstructive jaundice with a tumor genesis (23.4%) or non-tumor genesis (76.6%). The patients were hospitalized at different stages of clinical signs of jaundice. We studied the anti-peroxide activity in plasma, basal and stimulated indicators of the chemiluminescence intensity in leukocytes, leukocyte activity coefficients reflecting the level of reactive oxygen species generated by leukocytes, malondialdehyde levels indicative of the degree of lipid peroxidation and cellular destruction, liver enzymes (markers of cytolysis) and bilirubin levels. Data for hepatocyte death and markers of oxidative stress correlated with the severity of jaundice, its duration and the method of its surgical correction. It is proposed that using markers of free radical processes to assess the prognosis and effectiveness of treatment and to personalize treatment measures will improve the results of jaundice treatment. |
