The estrous cycle and 17β-estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons.

Autor: Krentzel AA; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA., Proaño SB; Neurobiology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA., Dorris DM; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA., Setzer B; Graduate Program for Neuroscience and Department of Biomedical Engineering, Boston University, Boston, MA, USA., Meitzen J; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Jazyk: angličtina
Zdroj: Journal of neuroendocrinology [J Neuroendocrinol] 2022 Jun; Vol. 34 (6), pp. e13122. Date of Electronic Publication: 2022 Apr 02.
DOI: 10.1111/jne.13122
Abstrakt: The nucleus accumbens core is a key nexus within the mammalian brain for integrating the premotor and limbic systems and regulating important cognitive functions such as motivated behaviors. Nucleus accumbens core functions show sex differences and are sensitive to the presence of hormones such as 17β-estradiol (estradiol) in normal and pathological contexts. The primary neuron type of the nucleus accumbens core, the medium spiny neuron (MSN), exhibits sex differences in both intrinsic excitability and glutamatergic excitatory synapse electrophysiological properties. Here, we provide a review of recent literature showing how estradiol modulates rat nucleus accumbens core MSN electrophysiology within the context of the estrous cycle. We review the changes in MSN electrophysiological properties across the estrous cycle and how these changes can be mimicked in response to exogenous estradiol exposure. We discuss in detail recent findings regarding how acute estradiol exposure rapidly modulates excitatory synapse properties in nucleus accumbens core but not caudate-putamen MSNs, which mirror the natural changes seen across estrous cycle phases. These recent insights demonstrate the strong impact of sex-specific estradiol action upon nucleus accumbens core neuron electrophysiology.
(© 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje