Extremely premature infants born at 23-25 weeks gestation are at substantial risk for pulmonary hypertension.

Autor: Sallmon H; Department of Pediatric Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany. sallmon@dhzb.de.; Department of Congenital Heart Disease/Pediatric Cardiology, Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany. sallmon@dhzb.de.; European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany. sallmon@dhzb.de., Koestenberger M; European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.; Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria., Avian A; Institute for Medical Informatics, Statistics and Documentation, Medical University Graz, Graz, Austria., Reiterer F; Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University of Graz, Graz, Austria., Schwaberger B; Division of Neonatology, Department of Pediatrics and Adolescence Medicine, Medical University of Graz, Graz, Austria., Meinel K; European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.; Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria., Cvirn G; Physiological Chemistry Division, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Kurath-Koller S; European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.; Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria., Gamillscheg A; Division of Pediatric Cardiology, Department of Pediatrics, Medical University Graz, Graz, Austria., Hansmann G; European Pediatric Pulmonary Vascular Disease Network, Berlin, Germany.; Department of Pediatric Cardiology and Critical Care, Hannover Medical School, Hannover, Germany.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Jun; Vol. 42 (6), pp. 781-787. Date of Electronic Publication: 2022 Apr 01.
DOI: 10.1038/s41372-022-01374-w
Abstrakt: Objective: Extremely low gestational age newborns (ELGANs) represent an especially vulnerable population. Herein, we aimed to determine incidence and severity of pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH) in extremely immature ELGANs (gestational age: 23 0/6 -25 6/7 weeks).
Methods: In this prospective observational cohort study, we assessed BPD-PH by means of several echocardiography markers and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 3 and 12 months of chronological age. In addition, we analyzed incidence and efficacy of pharmacologic treatment for BPD-PH.
Results: At 3 months 15/34 ELGANs had echocardiographic evidence of BPD-PH, while at 12 months of age 6/34 still had PH. PH-targeted therapy consisted of sildenafil monotherapy in 11 and dual oral combination therapy (sildenafil and macitentan) in four ELGANs at 3 and 12 months.
Conclusion: 44% (15/34) of ELGANs developed BPD-PH. All received PH-targeted pharmacotherapy at 3 months, leading to hemodynamic improvements at 12 months in most infants.
(© 2022. The Author(s).)
Databáze: MEDLINE
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