UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma.

Autor: Puttonen M; Department of Pathology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland. maya.puttonen@helsinki.fi., Isola J; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Ylinen O; Jilab Inc, Tampere, Finland., Böhling T; Department of Pathology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland., Koljonen V; Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Sihto H; Department of Pathology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Apr 01; Vol. 12 (1), pp. 5529. Date of Electronic Publication: 2022 Apr 01.
DOI: 10.1038/s41598-022-09490-5
Abstrakt: Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant transformation. However, the impact of chronic light exposure on the microenvironment of EPCs and EPs has not been investigated yet. Although the clinical relevance of tumour infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) has been established in various tumours, their distribution and significance in EPCs and EPs is still poorly understood. We characterized the distribution of TILs and TLSs using CD3, CD4, CD8, CD20 immunohistochemistry in a cohort of 10 EPCs and 49 EPs. We then classified our samples using solar-elastosis grading, analyzing the influence of ultraviolet (UV) damage on TIL density. A negative correlation between UV damage and TIL density was observed (CD4 r = -0.286, p = 0.04. CD8 r = -0.305, p = 0.033). No significant difference in TIL density was found between EPCs and EPs. TLS was scarse with the presence rate 10% in EPCs and 8.3% in EPs. The results suggest that UV has an immunosuppressive effect on the microenvironment of EPCs and EPs.
(© 2022. The Author(s).)
Databáze: MEDLINE
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